Spero Therapeutics, Inc. (SPRO)

NASDAQ: SPRO · USD

$1.15

+0.01 (+0.9%)· Recorded snapshot

Market cap	67M
Revenue (ttm)	47M
Net income (ttm)	7.4M
EPS (ttm)	$0.13
Shares out	58.2M
P/E (trailing)	9.0x
Volume	321,349
Beta	1.50

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Revenue (ttm): 47M
Net income (ttm): 7.4M
EPS (ttm): $0.13
P/E (trailing): 9.0x
Market cap: 67M

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	Halten

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector percentile context

Refreshed 2026-10-28 19:55 UTC

Forward P/En/a

P25 n/aP50 n/aP75 n/a

Trailing P/E9

P25 n/aP50 n/aP75 n/a

ROE19.2

P25 n/aP50 n/aP75 n/a

ROIC32.1

P25 n/aP50 n/aP75 n/a

Benchmarks · 1M

All SPRO indicators

Market & fundamental data

Available fields

210

Groups with data

Currency

USD

Showing 210 of 210 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Amount currency	USD
CIK code	0001701108
Company name	Spero Therapeutics, Inc.
Country	United States
Country code	US
CUSIP number	84833T103
Earnings date	2026-11-12
Earnings time	amc
Employees	25
Employees change	-7
Employees growth	-21.88%
Enterprise value	$18.2M
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	2013
Industry	Biotechnology
IPO date	2017-11-02
Is primary listing	Yes
Is SPAC	No
ISIN number	US84833T1034
Last 10-K release date	2026-03-26
Last earnings date	2026-08-12
Last refreshed	2026-10-28
Last stock split type	Never
Market cap	$67M
Market cap category	Micro-Cap
Next earnings date	2026-11-12
Options	Yes
Price	$1.15
Price currency	USD
Sector	Healthcare
SIC code	2834
Stock price date	2026-10-28
Symbol	SPRO
U.S. state	Massachusetts
Website	https://sperotherapeutics.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings yield	11.11%
EV/Earnings	2.39x
EV/EBIT	2.67x
EV/FCF	0.9x
EV/Sales	0.38x
FCF / EV yield	110.89%
FCF yield	29.49%
Graham number	1.47839
Graham upside	29.68%
P/(FCF - SBC) ratio	4.26x
P/(OCF - SBC) ratio	4.26x
P/B ratio	1.5x
P/E ratio	9x
P/FCF ratio	3.39x
P/OCF ratio	3.39x
P/S ratio	1.41x
Price / tangible book value	1.5x
Sector forward P/E	23.56x
Sector P/E	50.13x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
EBIT margin	14.07%
Effective tax rate	3.41%
FCF margin	41.66%
Gross margin	56.31%
Operating margin	14.07%
Pretax margin	16.26%
Profit margin	15.71%
Profit per employee	$295,320
Profitable years	1
Revenue per employee	$1.9M
ROA	7.19%
ROA (5Y)	-12.37%
ROCE	14.91%
ROE	19.17%
ROE (5Y)	-37.27%
ROIC	32.09%
SBC / revenue	8.49%
Tax / revenue	0.56%

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
EPS growth years	1
FCF growth 3Y	17.38%
Gross profit growth 3Y	25.79%
Net income growth years	1
OCF growth 3Y	17.38%
Revenue growth	-3.25%
Revenue growth 3Y	-4.66%
Revenue growth 5Y	20.69%
Revenue growth years	1

Financial statements

Income-statement and cash-flow amounts, totals and per share.

Metric	Value
EBIT	$6.6M
EPS	$0.13
FCF per share	$0.34
Free cash flow	$19.6M
Free cash flow minus SBC	$15.6M
Gross profit	$26.5M
Income taxes	$261,000
Net cash flow	$19.6M
Net income	$7.4M
Operating cash flow minus SBC	$15.6M
Operating income	$6.6M
Revenue	$47M
Stock-based compensation	$4M

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Altman Z-Score	-0.68
Book value per share	$0.76
Debt / EBITDA	0.25
Debt / equity	0.05
Debt / FCF	0.1
Long-term assets	$1.2M
Long-term liabilities	$134,000
Net cash (debt)	$48.7M
Net cash / market cap	73.4%
Net cash growth	76.7%
Net debt / equity	-1.1
Net debt / FCF	-2.49
Piotroski F-Score	7
Property, plant and equipment	$1M
Shareholders' equity	$44.2M
Tangible book value	$44.2M
Tangible book value per share	$0.76
Total assets	$52.8M
Total cash	$50.8M
Total debt	$2M
Total liabilities	$8.6M
WACC	12.12%

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Asset turnover	0.82
Current assets	$51.6M
Current liabilities	$8.4M
Current ratio	6.12
Net working capital	$-5.6M
Quick ratio	6.03
Working capital	$43.2M
Working capital turnover	1.07

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback yield / dilution	-9.06%
Dividend yield	0%
Shareholder yield	-9.06%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
150-day SMA	$1.88
1D price change	0.88%
1M price change	-6.1%
1M total return	-6.1%
1W price change	-5.33%
1W total return	-5.33%
1Y price change	-49.56%
1Y return CAGR	-49.59%
1Y total return	-49.56%
20-day SMA	$1.16
200-day SMA	$2.00
3M price change	-2.12%
3M total return	-2.12%
3Y price change	13.24%
3Y return CAGR	4.23%
3Y total return	13.24%
50-day SMA	$1.18
50-day SMA vs 200-day SMA	50under200
52-week high	$3.08
52-week high date	2026-05-27
52-week low	$1.04
52-week low date	2026-10-27
5Y price change	-92.94%
5Y return CAGR	-41.15%
5Y total return	-92.94%
6M price change	-56.74%
6M total return	-56.74%
All-time high	$23.64
All-time high date	2020-12-28
All-time low	$0.51
All-time low date	2025-04-09
Average true range (ATR)	$0.07
Average volume	479.5K
Beta (1Y)	1.34
Beta (2Y)	1.84
Beta (5Y)	1.5
Change from 52-week high	-62.66%
Change from 52-week low	10.58%
Change from all-time high	-95.11%
Change from all-time low	128.62%
Change from open	0%
Day's gap	0.88%
Dollar volume	$369,551
High price	$1.15
Low price	$1.13
Monthly RSI	39.54
Open price	$1.15
Position in 52-week range	100%
Premarket change	3.51%
Premarket close	$1.14
Premarket price	$1.18
Premarket volume	78.2K
Previous close	$1.14
Price vs 150-day SMA	-38.43%
Price vs 20-day SMA	0%
Price vs 200-day SMA	-42.16%
Price vs 50-day SMA	-2.12%
Relative volume	0.67
RSI	49.22
Sharpe ratio	-0.81
Sharpe ratio (3Y)	0.37
Sharpe ratio (5Y)	0.07
Sortino ratio	-0.99
Sortino ratio (3Y)	1.47
Sortino ratio (5Y)	0.27
Volume	321.3K
Weekly RSI	32.66
YTD price change	-50.43%
YTD total return	-50.43%

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	47.1M
Float percentage	80.88%
Shares change (QoQ)	1.2%
Shares change (YoY)	9.06%
Shares held by insiders	3.34%
Shares held by institutions	21.09%
Shares outstanding	58.2M
Short % of float	1.78%
Short % of shares	1.44%
Short ratio	1.1 days

Deeper analysis on SPRO

14 sections in the full report · jump straight to what you need

Forecast

Base and Bull forecast paths with report-date return framing.

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Valuation

Fair-value bridge, DCF, owner earnings, and peer multiples.

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Sensitivity

Cost-of-equity and terminal-growth stress table.

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Risks

Kill scenarios, soft-pass flags, and downside catalysts.

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Earnings

Next earnings setup and beat / inline / miss thresholds.

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Position sizing

Entry, exit, conviction, and quarterly monitoring rules.

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Financials

Revenue, margins, cash flow, and balance-sheet context.

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Peers

Relative valuation and profitability against the cohort.

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Moat

Economic-profit evidence and competitive advantage risk.

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Industry cycle

Sector phase, capital cycle, and secular tailwinds.

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Frequently asked questions

About this SPRO report

Is a complete SPRO research report available?

No complete published report is available for Spero Therapeutics, Inc. (SPRO) on this page. Market-directory data, when present, is not a substitute for a validated stock analysis.

Spero Therapeutics, Inc. (SPRO)

Price

Financial snapshot

Fair-value bridge

Latest news · SPRO

Valuation

Profitability

Balance sheet

Trading

Next earnings

Sector percentile context

All SPRO indicators

Profile and market data

Valuation

Profitability

Growth

Financial statements

Financial strength

Liquidity

Dividends and buybacks

Performance and technicals

Ownership and float

Deeper analysis on SPRO

Frequently asked questions