Upstream Bio, Inc. (UPB)

NASDAQ: UPB · USD

$2.98

+0.18 (+6.6%)· Recorded snapshot

Market cap	162.9M
Revenue (ttm)	3.2M
Net income (ttm)	-156.5M
EPS (ttm)	-$2.89
Shares out	54.8M
Volume	1,204,558
Beta	1.39

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Revenue (ttm): 3.2M
Net income (ttm): -156.5M
EPS (ttm): -$2.89
Market cap: 162.9M

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	Mantenere

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector percentile context

Refreshed 2026-10-28 19:55 UTC

Forward P/En/a

P25 n/aP50 n/aP75 n/a

Trailing P/En/a

P25 n/aP50 n/aP75 n/a

ROE-46

P25 n/aP50 n/aP75 n/a

ROIC-31.1

P25 n/aP50 n/aP75 n/a

Benchmarks · 1M

All UPB indicators

Market & fundamental data

Available fields

185

Groups with data

Currency

USD

Showing 185 of 185 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Amount currency	USD
CIK code	0002022626
Company name	Upstream Bio, Inc.
Country	United States
Country code	US
CUSIP number	91678A107
Earnings date	2026-11-09
Earnings time	bmo
Employees	75
Enterprise value	$-97.4M
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	2021
In index	RUSSELL2000
Industry	Biotechnology
IPO date	2024-10-11
Is primary listing	Yes
Is SPAC	No
ISIN number	US91678A1079
Last 10-K release date	2026-03-26
Last earnings date	2026-08-11
Last refreshed	2026-10-28
Last stock split type	Never
Market cap	$162.9M
Market cap category	Micro-Cap
Next earnings date	2026-11-09
Options	Yes
Price	$2.98
Price currency	USD
Sector	Healthcare
SIC code	2834
Stock price date	2026-10-28
Symbol	UPB
U.S. state	Massachusetts
Website	https://upstreambio.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings yield	-97%
FCF / EV yield	131.24%
FCF yield	-87.27%
Forward P/S	104.07x
P/B ratio	0.56x
P/S ratio	49.52x
Price / tangible book value	0.58x
Sector forward P/E	23.56x
Sector P/E	50.08x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
Gross margin	100%
Operating margin	-5,382.65%
Pretax margin	-4,955.67%
Profit per employee	$-2.1M
Revenue per employee	$42,107
ROA	-30.28%
ROCE	-62.68%
ROE	-46.05%
ROIC	-31.15%
SBC / revenue	446.52%

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
EPS growth quarters	1
EPS growth years	2
Gross profit growth	15.98%
Gross profit growth (Q)	-17.5%
Net income growth quarters	1
Net income growth years	0
Revenue growth	15.98%
Revenue growth (Q)	-17.5%
Revenue growth (QoQ)	-25.24%
Revenue growth years	1

Financial statements

Income-statement and cash-flow amounts, totals and per share.

Metric	Value
Capital expenditures	$-118,000
Depreciation and amortization	$202,000
EBIT	$-170M
EBITDA	$-169.8M
EPS	$-2.89
FCF per share	$-2.49
Financing cash flow	$5M
Free cash flow	$-136.5M
Free cash flow minus SBC	$-150.6M
Gross profit	$3.2M
Investing cash flow	$165.3M
Net cash flow	$33.9M
Net income	$-156.5M
Operating cash flow minus SBC	$-150.4M
Operating income	$-170M
Revenue	$3.2M
Stock-based compensation	$14.1M

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Altman Z-Score	50.27
Book value per share	$4.95
Debt / equity	0
Long-term assets	$1.6M
Long-term liabilities	$226,000
Net cash (debt)	$260.4M
Net cash / market cap	166.5%
Net cash growth	-33.59%
Net debt / equity	-0.96
Piotroski F-Score	2
Property, plant and equipment	$1.4M
Shareholders' equity	$271M
Tangible book value	$271M
Tangible book value per share	$4.95
Total assets	$281.2M
Total cash	$261.3M
Total debt	$954,000
Total liabilities	$10.2M
WACC	11.82%

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Asset turnover	0.01
Current assets	$279.6M
Current liabilities	$10M
Current ratio	27.99
Net working capital	$9M
Quick ratio	26.38
Working capital	$269.6M
Working capital turnover	0.01

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback yield / dilution	-38.95%
Dividend yield	0%
Shareholder yield	-38.95%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
150-day SMA	$6.99
1D price change	6.63%
1M price change	-44.5%
1M total return	-44.5%
1W price change	6.25%
1W total return	6.25%
1Y price change	-87.38%
1Y return CAGR	-87.4%
1Y total return	-87.38%
20-day SMA	$3.67
200-day SMA	$9.57
3M price change	-53.52%
3M total return	-53.52%
50-day SMA	$5.08
50-day SMA vs 200-day SMA	50under200
52-week high	$33.68
52-week high date	2026-01-14
52-week low	$2.68
52-week low date	2026-10-28
6M price change	-67.98%
6M total return	-67.98%
All-time high	$33.68
All-time high date	2026-01-14
All-time low	$2.68
All-time low date	2026-10-27
Average true range (ATR)	$0.33
Average volume	1.3M
Beta (1Y)	2.93
Beta (2Y)	1.38
Beta (5Y)	1.39
Change from 52-week high	-91.17%
Change from 52-week low	11.01%
Change from all-time high	-91.17%
Change from all-time low	11.01%
Change from open	8.97%
Day's gap	-2.15%
Dollar volume	$3.6M
High price	$2.99
Low price	$2.69
Monthly RSI	31.78
Open price	$2.73
Position in 52-week range	96.61%
Premarket change	-2.15%
Premarket close	$2.79
Premarket price	$2.73
Premarket volume	200
Previous close	$2.79
Price vs 150-day SMA	-57.42%
Price vs 20-day SMA	-18.85%
Price vs 200-day SMA	-68.9%
Price vs 50-day SMA	-41.45%
Relative volume	0.94
Return from IPO open	-86.72%
Return from IPO price	-83.21%
RSI	28.14
Sharpe ratio	-1.82
Sortino ratio	-2.03
Volume	1.2M
Weekly RSI	26.08
YTD price change	-89.04%
YTD total return	-89.04%

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	42.8M
Float percentage	78.16%
Shares change (QoQ)	0.43%
Shares change (YoY)	38.95%
Shares held by insiders	0.07%
Shares held by institutions	75.91%
Shares outstanding	54.8M
Short % of float	10.55%
Short % of shares	8.24%
Short ratio	7.1 days

Deeper analysis on UPB

14 sections in the full report · jump straight to what you need

Forecast

Base and Bull forecast paths with report-date return framing.

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Valuation

Fair-value bridge, DCF, owner earnings, and peer multiples.

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Sensitivity

Cost-of-equity and terminal-growth stress table.

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Risks

Kill scenarios, soft-pass flags, and downside catalysts.

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Earnings

Next earnings setup and beat / inline / miss thresholds.

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Position sizing

Entry, exit, conviction, and quarterly monitoring rules.

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Financials

Revenue, margins, cash flow, and balance-sheet context.

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Peers

Relative valuation and profitability against the cohort.

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Moat

Economic-profit evidence and competitive advantage risk.

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Industry cycle

Sector phase, capital cycle, and secular tailwinds.

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Frequently asked questions

About this UPB report

Is a complete UPB research report available?

No complete published report is available for Upstream Bio, Inc. (UPB) on this page. Market-directory data, when present, is not a substitute for a validated stock analysis.

Upstream Bio, Inc. (UPB)

Price

Financial snapshot

Fair-value bridge

Latest news · UPB

Valuation

Profitability

Balance sheet

Trading

Next earnings

Sector percentile context

All UPB indicators

Profile and market data

Valuation

Profitability

Growth

Financial statements

Financial strength

Liquidity

Dividends and buybacks

Performance and technicals

Ownership and float

Deeper analysis on UPB

Frequently asked questions