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Ionis Pharmaceuticals, Inc. (IONS)

NASDAQ: IONS · USD

$44.9

+0.93 (+2.1%)· Recorded snapshot

Market cap	7.5B
Revenue (ttm)	874.1M
Net income (ttm)	-565.2M
EPS (ttm)	-$3.46
Shares out	166.2M
Volume	1,380,630
Beta	0.38

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Revenue (ttm): 874.1M
Net income (ttm): -565.2M
EPS (ttm): -$3.46
Market cap: 7.5B

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	ホールド

Metric	Value
Amount currency	USD
CIK code	0000874015
Company name	Ionis Pharmaceuticals, Inc.
Country	United States
Country code	US
CUSIP number	462222100
Earnings date	2026-11-10
Earnings time	bmo
Employees	1,480
Employees change	78
Employees growth	5.56%
Enterprise value	$7.5B
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	1989
Industry	Biotechnology
IPO date	1991-05-17
Is primary listing	Yes
Is SPAC	No
ISIN number	US4622221004
Last 10-K release date	2026-02-26
Last earnings date	2026-07-29
Last refreshed	2026-10-28
Last stock split type	Never
Market cap	$7.5B
Market cap category	Mid-Cap
Next earnings date	2026-11-10
Options	Yes
Price	$44.89
Price currency	USD
Sector	Healthcare
SIC code	2834
Stock price date	2026-10-28
Symbol	IONS
U.S. state	California
Website	https://www.ionis.com

Metric

Value

Amount currency

USD

CIK code

0000874015

Company name

Ionis Pharmaceuticals, Inc.

Country

United States

Country code

CUSIP number

462222100

Earnings date

2026-11-10

Earnings time

bmo

Employees

1,480

Employees change

Employees growth

5.56%

Enterprise value

$7.5B

Exchange

NASDAQ

Financial currency

USD

Financial report date

2026-06-30

First seen

2026-05-09

Fiscal year end

December

Founded

1989

Industry

Biotechnology

IPO date

1991-05-17

Is primary listing

Yes

Is SPAC

ISIN number

US4622221004

Last 10-K release date

2026-02-26

Last earnings date

2026-07-29

Last refreshed

2026-10-28

Last stock split type

Never

Market cap

$7.5B

Market cap category

Mid-Cap

Next earnings date

2026-11-10

Options

Yes

Price

$44.89

Price currency

USD

Sector

Healthcare

SIC code

2834

Stock price date

2026-10-28

Symbol

IONS

U.S. state

California

Website

https://www.ionis.com

Metric	Value
Earnings yield	-7.72%
EV/Sales	8.48x
FCF / EV yield	-7.57%
FCF yield	-7.66%
Forward EV/Sales	7.67x
Forward P/S	7.58x
P/B ratio	16.56x
P/S ratio	8.38x
Price / tangible book value	16.65x
Sector forward P/E	23.56x
Sector P/E	50.08x

Metric

Value

Earnings yield

-7.72%

EV/Sales

8.48x

FCF / EV yield

-7.57%

FCF yield

-7.66%

Forward EV/Sales

7.67x

Forward P/S

7.58x

P/B ratio

16.56x

P/S ratio

8.38x

Price / tangible book value

16.65x

Sector forward P/E

23.56x

Sector P/E

50.08x

Metric	Value
EBIT margin	-68%
EBITDA margin	-66.3%
Gross margin	-6.93%
Operating margin	-68%
Pretax margin	-64.3%
Profit margin	-64.66%
Profit per employee	$-381,874
Revenue per employee	$590,603
ROA	-12.42%
ROA (5Y)	-7.19%
ROCE	-22.19%
ROE	-105.5%
ROE (5Y)	-56.83%
ROIC	-72.03%
SBC / revenue	18.69%
Tax / revenue	0.36%

Metric

Value

EBIT margin

-68%

EBITDA margin

-66.3%

Gross margin

-6.93%

Operating margin

-68%

Pretax margin

-64.3%

Profit margin

-64.66%

Profit per employee

$-381,874

Revenue per employee

$590,603

ROA

-12.42%

ROA (5Y)

-7.19%

ROCE

-22.19%

ROE

-105.5%

ROE (5Y)

-56.83%

ROIC

-72.03%

SBC / revenue

18.69%

Tax / revenue

0.36%

Metric	Value
EPS growth years	1
FCF growth (Q)	295.2%
Gross profit growth (Q)	-75.13%
Net income growth years	1
OCF growth (Q)	273.69%
Revenue growth	-7.41%
Revenue growth (Q)	-40.73%
Revenue growth (QoQ)	8.88%
Revenue growth 10Y	17.38%
Revenue growth 3Y	11.5%
Revenue growth 5Y	4.91%
Revenue growth years	1

Metric

Value

EPS growth years

FCF growth (Q)

295.2%

Gross profit growth (Q)

-75.13%

Net income growth years

OCF growth (Q)

273.69%

Revenue growth

-7.41%

Revenue growth (Q)

-40.73%

Revenue growth (QoQ)

8.88%

Revenue growth 10Y

17.38%

Revenue growth 3Y

11.5%

Revenue growth 5Y

4.91%

Revenue growth years

Metric	Value
Capital expenditures	$-64.4M
Depreciation and amortization	$14.9M
EBIT	$-594.4M
EBITDA	$-579.5M
EPS	$-3.46
FCF per share	$-3.37
Financing cash flow	$317.4M
Free cash flow	$-560.8M
Free cash flow minus SBC	$-724.2M
Gross profit	$-60.6M
Income taxes	$3.2M
Investing cash flow	$232.2M
Net borrowing	$69.7M
Net cash flow	$52.8M
Net income	$-565.2M
Operating cash flow minus SBC	$-659.8M
Operating income	$-594.4M
Revenue	$874.1M
Stock-based compensation	$163.3M

Metric

Value

Capital expenditures

$-64.4M

Depreciation and amortization

$14.9M

EBIT

$-594.4M

EBITDA

$-579.5M

EPS

$-3.46

FCF per share

$-3.37

Financing cash flow

$317.4M

Free cash flow

$-560.8M

Free cash flow minus SBC

$-724.2M

Gross profit

$-60.6M

Income taxes

$3.2M

Investing cash flow

$232.2M

Net borrowing

$69.7M

Net cash flow

$52.8M

Net income

$-565.2M

Operating cash flow minus SBC

$-659.8M

Operating income

$-594.4M

Revenue

$874.1M

Stock-based compensation

$163.3M

Metric	Value
Altman Z-Score	1.83
Book value per share	$2.65
Debt / equity	4.98
Interest coverage	-6.64
Long-term assets	$503.2M
Long-term liabilities	$2.2B
Net cash (debt)	$-86.7M
Net cash / market cap	-1.18%
Net debt / equity	0.2
Piotroski F-Score	2
Property, plant and equipment	$386.7M
Shareholders' equity	$439.7M
Tangible book value	$439.7M
Tangible book value per share	$2.65
Total assets	$3B
Total cash	$2.1B
Total debt	$2.2B
Total liabilities	$2.6B
WACC	5.63%

Metric

Value

Altman Z-Score

1.83

Book value per share

$2.65

Debt / equity

4.98

Interest coverage

-6.64

Long-term assets

$503.2M

Long-term liabilities

$2.2B

Net cash (debt)

$-86.7M

Net cash / market cap

-1.18%

Net debt / equity

0.2

Piotroski F-Score

Property, plant and equipment

$386.7M

Shareholders' equity

$439.7M

Tangible book value

$439.7M

Tangible book value per share

$2.65

Total assets

$3B

Total cash

$2.1B

Total debt

$2.2B

Total liabilities

$2.6B

WACC

5.63%

Metric	Value
Asset turnover	0.29
Current assets	$2.5B
Current liabilities	$315.6M
Current ratio	7.89
Inventory turnover	31.52
Net working capital	$86.2M
Quick ratio	6.85
Working capital	$2.2B
Working capital turnover	0.45

Metric

Value

Asset turnover

0.29

Current assets

$2.5B

Current liabilities

$315.6M

Current ratio

7.89

Inventory turnover

31.52

Net working capital

$86.2M

Quick ratio

6.85

Working capital

$2.2B

Working capital turnover

0.45

Metric	Value
Buyback yield / dilution	-4.49%
Dividend yield	0%
Shareholder yield	-4.49%

Metric

Value

Buyback yield / dilution

-4.49%

Dividend yield

Shareholder yield

-4.49%

Metric	Value
10Y price change	71.76%
10Y return CAGR	5.56%
10Y total return	71.76%
150-day SMA	$63.15
15Y price change	419.12%
15Y return CAGR	11.61%
15Y total return	419.12%
1D price change	2.12%
1M price change	-0.84%
1M total return	-0.84%
1W price change	-2.81%
1W total return	-2.81%
1Y price change	-39.55%
1Y return CAGR	-39.57%
1Y total return	-39.55%
20-day SMA	$43.80
200-day SMA	$67.13
20Y price change	429.08%
20Y return CAGR	8.69%
20Y total return	429.08%
3M price change	-21.15%
3M total return	-21.15%
3Y price change	0.17%
3Y return CAGR	0.06%
3Y total return	0.17%
50-day SMA	$49.64
50-day SMA vs 200-day SMA	50under200
52-week high	$86.74
52-week high date	2026-07-08
52-week low	$42.08
52-week low date	2026-10-14
5Y price change	48.02%
5Y return CAGR	8.16%
5Y total return	48.02%
6M price change	-38.91%
6M total return	-38.91%
All-time high	$86.74
All-time high date	2026-02-05
All-time low	$2.50
All-time low date	2003-03-17
Average true range (ATR)	$1.64
Average volume	2.7M
Beta (1Y)	0.7
Beta (2Y)	0.93
Beta (5Y)	0.38
Change from 52-week high	-48.25%
Change from 52-week low	6.68%
Change from all-time high	-49.13%
Change from all-time low	1,665%
Change from open	3.34%
Day's gap	-1.18%
Dollar volume	$62M
High price	$44.93
Low price	$43.35
Monthly RSI	42.02
Open price	$43.44
Position in 52-week range	97.47%
Premarket change	-0.84%
Premarket close	$43.96
Premarket price	$43.59
Premarket volume	814
Previous close	$43.96
Price vs 150-day SMA	-30.13%
Price vs 20-day SMA	0.74%
Price vs 200-day SMA	-34.27%
Price vs 50-day SMA	-11.1%
Relative volume	0.51
RSI	44.94
Sharpe ratio	-1.05
Sharpe ratio (3Y)	0.1
Sharpe ratio (5Y)	0.29
Sortino ratio	-1.14
Sortino ratio (3Y)	0.29
Sortino ratio (5Y)	0.57
Volume	1.4M
Weekly RSI	33.38
YTD price change	-44.22%
YTD total return	-44.22%

Metric

Value

10Y price change

71.76%

10Y return CAGR

5.56%

10Y total return

71.76%

150-day SMA

$63.15

15Y price change

419.12%

15Y return CAGR

11.61%

15Y total return

419.12%

1D price change

2.12%

1M price change

-0.84%

1M total return

-0.84%

1W price change

-2.81%

1W total return

-2.81%

1Y price change

-39.55%

1Y return CAGR

-39.57%

1Y total return

-39.55%

20-day SMA

$43.80

200-day SMA

$67.13

20Y price change

429.08%

20Y return CAGR

8.69%

20Y total return

429.08%

3M price change

-21.15%

3M total return

-21.15%

3Y price change

0.17%

3Y return CAGR

0.06%

3Y total return

0.17%

50-day SMA

$49.64

50-day SMA vs 200-day SMA

50under200

52-week high

$86.74

52-week high date

2026-07-08

52-week low

$42.08

52-week low date

2026-10-14

5Y price change

48.02%

5Y return CAGR

8.16%

5Y total return

48.02%

6M price change

-38.91%

6M total return

-38.91%

All-time high

$86.74

All-time high date

2026-02-05

All-time low

$2.50

All-time low date

2003-03-17

Average true range (ATR)

$1.64

Average volume

2.7M

Beta (1Y)

0.7

Beta (2Y)

0.93

Beta (5Y)

0.38

Change from 52-week high

-48.25%

Change from 52-week low

6.68%

Change from all-time high

-49.13%

Change from all-time low

1,665%

Change from open

3.34%

Day's gap

-1.18%

Dollar volume

$62M

High price

$44.93

Low price

$43.35

Monthly RSI

42.02

Open price

$43.44

Position in 52-week range

97.47%

Premarket change

-0.84%

Premarket close

$43.96

Premarket price

$43.59

Premarket volume

814

Previous close

$43.96

Price vs 150-day SMA

-30.13%

Price vs 20-day SMA

0.74%

Price vs 200-day SMA

-34.27%

Price vs 50-day SMA

-11.1%

Relative volume

0.51

RSI

44.94

Sharpe ratio

-1.05

Sharpe ratio (3Y)

0.1

Sharpe ratio (5Y)

0.29

Sortino ratio

-1.14

Sortino ratio (3Y)

0.29

Sortino ratio (5Y)

0.57

Volume

1.4M

Weekly RSI

33.38

YTD price change

-44.22%

YTD total return

-44.22%

Metric	Value
Float	164.8M
Float percentage	99.18%
Shares change (QoQ)	0.33%
Shares change (YoY)	4.49%
Shares held by insiders	0.78%
Shares held by institutions	109.96%
Shares outstanding	166.2M
Short % of float	12.53%
Short % of shares	12.43%
Short ratio	5.1 days

Metric

Value

Float

164.8M

Float percentage

99.18%

Shares change (QoQ)

0.33%

Shares change (YoY)

4.49%

Shares held by insiders

0.78%

Shares held by institutions

109.96%

Shares outstanding

166.2M

Short % of float

12.53%

Short % of shares

12.43%

Short ratio

5.1 days

Ionis Pharmaceuticals, Inc. (IONS)

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