Healthcare / BiotechnologyUpdated 2026-05-10 22:07 UTC

SYRE stock hub

Spyre Therapeutics, Inc. has a live ticker hub with the latest available market, valuation, profitability, growth, ownership, and risk indicators.

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Fair value midpoint

n/a

Fair value pending

Upside to midpoint

n/a

Based on latest report

Confidence

n/a

Data quality and model convergence

Market cap

6.5B

NASDAQ

Market data

Live price

Current market quote for this ticker.

Current price

SYRE

In the news

Latest news · SYRE

Recent company headlines from major financial publishers.

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Fetching the latest headlines.

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Fetching the latest headlines.

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Fetching the latest headlines.

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector context

Where the current metrics sit

Percentiles come from the backend screener cohort cache for the ticker's country and sector.

Forward P/En/a

P25 12.3P50 18.4P75 33.1

Trailing P/En/a

P25 14.9P50 23.2P75 38.5

ROE-31.1

P25 -105.6P50 -46.5P75 -3.1

ROIC-26.2

P25 -63.1P50 -27.3P75 0.5

Benchmarks - 1M

S&P 500n/a

Nasdaq Compositen/a

Dow Jones Industrial Averagen/a

Russell 2000n/a

Indicator catalog

All SYRE market and fundamental indicators

A searchable catalog of the available market, valuation, profitability, growth, balance-sheet, ownership, and analyst metrics for this ticker.

Available fields

180

Groups with data

Currency

USD

Showing 180 of 180 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Cik	0001636282
Company name	Spyre Therapeutics, Inc.
Country	United States
Country code	US
Cusip	00773J202
Employees	112
Employees Change	39%
Employees Change Percent	53.42
Enterprise value	$5.8B
Exchange	NASDAQ
Financial currency	USD
First seen	2026-05-09
Industry	Biotechnology
IPO Date	2016-04-07
Isin	US00773J2024
Last refreshed	2026-05-10
Market cap	$6.5B
Market cap category	Mid-Cap
Price	$75.05
Price currency	USD
Sector	Healthcare
Sic	2834
Symbol	SYRE
Website	https://www.spyre.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings Yield	-2.28%
FCF yield	-2.85%
P/B ratio	11.49x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
Gross Profit	$-190.4M
Net Income	$-148.7M
Net Income Growth Years	2%
Profit Per Employee	$-1.3M
ROA	-22.65
Roa5y	-34.32
ROCE	-35.6
ROE	-31.11
Roe5y	-111.5
ROIC	-26.19

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
Cagr10y	-10.11%
Cagr1y	491.16%
Cagr3y	165.66%
Cagr5y	-16.15%
EPS Growth Years	6
Revenue Growth Years	0x

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Assets	$764M
Cash	$741.5M
Current Assets	$764M
Current Liabilities	$85.2M
Equity	$670.8M
Liabilities	$93.1M
Long Term Assets	$0
Long Term Liabilities	$8M
Net Cash	$741.5M
Net Cash By Market Cap	$11.38
Net Cash Growth	31.27%
Net Debt Equity	$-1.11
Tangible Book Value	$515M
Tangible Book Value Per Share	$6.53
WACC	21.46

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Current ratio	8.97
Net Working Capital	$-62.7M
Quick ratio	8.8
Working Capital	$678.8M

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback Yield	-29.57%
Dividend Yield	0%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
10Y total return	-65.54%
1Y total return	490.44%
200-day SMA	32.61
3Y total return	1,776.13%
50-day SMA	55.05
50-day SMA vs 200-day SMA	50over200
5Y total return	-58.54%
All Time High	318.8
All Time High Change	-76.46%
All Time High Date	2016-04-08
All Time Low	2.66
All Time Low Change	2,721.24%
All Time Low Date	2023-06-21
ATR	4.26
Beta	3.13
Beta1y	1.82
Beta2y	1.94
Ch YTD	129.1
High	75.91
High52	76
High52 Date	2026-05-01
High52ch	-1.26%
Low	72.4
Low52	12.29
Low52 Date	2025-05-08
Low52ch	510.87%
Ma50ch	36.32%
Premarket Change Percent	-0.12
Premarket Price	$73.01
Premarket Volume	3,353
Price vs 200-day SMA	130.1%
RSI	67.64
RSI Monthly	77.41
RSI Weekly	84.66
Sharpe ratio	2.9x
Sortino ratio	5.79
Total Return	-29.57%
Tr YTD	129.1
Tr1m	46.57%
Tr1w	8.1%
Tr3m	113.68%

Analyst estimates

Ratings, targets, revisions, and forward estimate fields.

Metric	Value
Analyst Count	12
Analyst Count Top	5
Analyst Price Target Top	$92
Analyst Ratings	Strong Buy
Analyst Ratings Top	Strong Buy
Earnings EPS Estimate	$-0.66
Operating Income	$-241.6M
Price target	$89.08
Price Target Change	$18.7
Price Target Change Top	$22.59

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	80,979,551%
Float Percent	93.25%
Shares Insiders	5.9%
Shares Institutions	95%
Shares Out	86,841,253
Shares Qo Q	4.61%
Shares Yo Y	29.57%
Short Float	14.41%
Short Ratio	9.41
Short Shares	13.44

Other indicators

Additional ticker metrics that do not fit the primary research groupings yet.

Metric	Value
Adjusted FCF	$-227.2M
Average Volume	1,581,231.3x
Bv Per Share	6.53
Ch10y	-65.54
Ch1m	46.57
Ch1w	8.1
Ch1y	490.4
Ch3m	113.7
Ch3y	1,776.1
Ch5y	-58.54
Ch6m	233.2
Change	2.66%
Change From Open	2.66
Close	73.1
Days Gap	0
Dollar Volume	63,081,251.1
Earnings Date	2026-05-05
Earnings Time	bmo
EBIT	$-241.6M
EPS	$-2.17
F Score	1
FCF	$-185.6M
FCF EV Yield	-3.21x
FCF Per Share	$-2.14
Financing CF	321,155,000
Fiscal Year End	December
Founded	2,013
Investing CF	-86,833,000
Is Primary Listing	1
Is Spac	No
Last Earnings Date	2026-05-05
Last Report Date	2026-03-31
Last Split Date	2023-09-08
Last Split Type	Reverse
Last10k Filing Date	2026-02-19
Ma150	38.03
Ma150ch	97.33%
Ma20	70.66
Ma20ch	6.21%
Net CF	48,692,000
Next Earnings Date	2026-08-04
Open	73.1
Optionable	Yes
Position In Range	75.36
Post Close	75.05
Postmarket Change Percent	-0.06
Postmarket Price	$75
Pre Close	73.1
Price Date	2026-05-08
Ptbv Ratio	12.65
Relative Volume	0.53x
Share Based Comp	41,561,000
Tr6m	233.24%
Us State	Massachusetts
Volume	840,579

Fast facts

Decision checkpoints

A compact product layer over the same report payload.

Risk gate

n/a

Named kill scenarios are reviewed before any bullish rating can stand.

Moat score

n/a

Business quality stays separate from stock attractiveness.

Forward P/E

n/a

Valuation uses the full report model stack, not a single multiple.

Next action

Research pending

Final action steps are kept in the recommendation tab.

Income

Does SYRE pay a dividend?

Capital-return profile for this ticker.

Performance

SYRE stock returns vs the market

Total return (incl. dividends) compared to S&P 500.

Ownership

Who owns SYRE?

Insider, institutional, and short-interest positioning.

Institutional ownership

+95.0%

Float: +93.3% of shares outstanding

Insider ownership

+5.9%

Stake held by company insiders. Higher generally signals alignment.

Negative means the company is buying back shares.

Technical

SYRE momentum and risk profile

RSI, moving-average stack, beta, and risk-adjusted return.

RSI (14)

67.6

Neutral momentum band

Price vs 200-day MA

+130.1%

50/200-day relationship not available

Beta (5Y)

3.13

More volatile than the market

Sharpe ratio

2.90

Risk-adjusted return — higher is better; >1.0 is solid.

Questions

About SYRE

Hub-level FAQ points readers to the deeper analysis pages.

What is the current SYRE stock rating?

Spyre Therapeutics, Inc. is currently shown with the latest rating in the latest report. The hub links directly to the full analysis surface where the rating, fair-value bridge, risks, and scorecard are documented together.

Where can I read the full SYRE analysis?

The full report lives at /stocks/SYRE/analysis. The bare ticker page is a product hub that summarizes the latest read and sends readers into the relocated analysis tabs without making the analysis surface depend on the hub.

What fair-value range is used for SYRE?

The latest report frames SYRE around the latest fair-value range. Treat that range as the entry point, then check the valuation, sensitivity, and bear-case tabs before making an investment decision.

How often is the SYRE page updated?

The hub updates with the latest published stock report and live backend market data. The analysis pages remain reachable under /analysis, so a hub rollback does not remove the report reader.