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Spyre Therapeutics, Inc. (SYRE)

NASDAQ: SYRE · USD

$99.5

+0.42 (+0.4%)· Recorded snapshot

Market cap	9.3B
Net income (ttm)	-150.2M
EPS (ttm)	-$2.01
Shares out	93.5M
Volume	590,076
Beta	3.11

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Net income (ttm): -150.2M
EPS (ttm): -$2.01
Market cap: 9.3B

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	Giữ

Metric	Value
Amount currency	USD
CIK code	0001636282
Company name	Spyre Therapeutics, Inc.
Country	United States
Country code	US
CUSIP number	00773J202
Earnings date	2026-11-10
Earnings time	amc
Employees	125
Employees change	38
Employees growth	43.68%
Enterprise value	$8.1B
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	2013
In index	RUSSELL2000
Industry	Biotechnology
IPO date	2016-04-07
Is primary listing	Yes
Is SPAC	No
ISIN number	US00773J2024
Last 10-K release date	2026-02-19
Last earnings date	2026-08-04
Last refreshed	2026-10-28
Last stock split date	2023-09-08
Last stock split type	Reverse
Market cap	$9.3B
Market cap category	Mid-Cap
Next earnings date	2026-11-10
Options	Yes
Price	$99.47
Price currency	USD
Sector	Healthcare
SIC code	2834
Stock price date	2026-10-28
Symbol	SYRE
U.S. state	Massachusetts
Website	https://www.spyre.com

Metric

Value

Amount currency

USD

CIK code

0001636282

Company name

Spyre Therapeutics, Inc.

Country

United States

Country code

CUSIP number

00773J202

Earnings date

2026-11-10

Earnings time

amc

Employees

125

Employees change

Employees growth

43.68%

Enterprise value

$8.1B

Exchange

NASDAQ

Financial currency

USD

Financial report date

2026-06-30

First seen

2026-05-09

Fiscal year end

December

Founded

2013

In index

RUSSELL2000

Industry

Biotechnology

IPO date

2016-04-07

Is primary listing

Yes

Is SPAC

ISIN number

US00773J2024

Last 10-K release date

2026-02-19

Last earnings date

2026-08-04

Last refreshed

2026-10-28

Last stock split date

2023-09-08

Last stock split type

Reverse

Market cap

$9.3B

Market cap category

Mid-Cap

Next earnings date

2026-11-10

Options

Yes

Price

$99.47

Price currency

USD

Sector

Healthcare

SIC code

2834

Stock price date

2026-10-28

Symbol

SYRE

U.S. state

Massachusetts

Website

https://www.spyre.com

Metric	Value
Earnings yield	-2.02%
FCF / EV yield	-2.58%
FCF yield	-2.26%
P/B ratio	9.14x
Price / tangible book value	9.7x
Sector forward P/E	23.56x
Sector P/E	50.08x

Metric

Value

Earnings yield

-2.02%

FCF / EV yield

-2.58%

FCF yield

-2.26%

P/B ratio

9.14x

Price / tangible book value

9.7x

Sector forward P/E

23.56x

Sector P/E

50.08x

Metric	Value
Profit per employee	$-1.2M
ROA	-19.81%
ROA (5Y)	-34.32%
ROCE	-24.45%
ROE	-22.98%
ROE (5Y)	-111.46%
ROIC	-21.79%

Metric

Value

Profit per employee

$-1.2M

ROA

-19.81%

ROA (5Y)

-34.32%

ROCE

-24.45%

ROE

-22.98%

ROE (5Y)

-111.46%

ROIC

-21.79%

Metric	Value
EPS growth quarters	1
EPS growth years	6
Net income growth quarters	1
Net income growth years	2
Revenue growth years	0

Metric

Value

EPS growth quarters

EPS growth years

Net income growth quarters

Net income growth years

Revenue growth years

Metric	Value
EBIT	$-271.3M
EPS	$-2.01
FCF per share	$-2.24
Financing cash flow	$753M
Free cash flow	$-208.9M
Free cash flow minus SBC	$-254.6M
Gross profit	$-215.8M
Investing cash flow	$-463.7M
Net cash flow	$80.3M
Net income	$-150.2M
Operating cash flow minus SBC	$-254.6M
Operating income	$-271.3M
Stock-based compensation	$45.7M

Metric

Value

EBIT

$-271.3M

EPS

$-2.01

FCF per share

$-2.24

Financing cash flow

$753M

Free cash flow

$-208.9M

Free cash flow minus SBC

$-254.6M

Gross profit

$-215.8M

Investing cash flow

$-463.7M

Net cash flow

$80.3M

Net income

$-150.2M

Operating cash flow minus SBC

$-254.6M

Operating income

$-271.3M

Stock-based compensation

$45.7M

Metric	Value
Book value per share	$10.84
Debt / equity	0
Long-term assets	$0
Long-term liabilities	$8.6M
Net cash (debt)	$1.1B
Net cash / market cap	12.37%
Net cash growth	117.51%
Net debt / equity	-1.04
Piotroski F-Score	1
Shareholders' equity	$1.1B
Tangible book value	$954.7M
Tangible book value per share	$10.84
Total assets	$1.2B
Total cash	$1.1B
Total debt	$0
Total liabilities	$71.9M
WACC	21.34%

Metric

Value

Book value per share

$10.84

Debt / equity

Long-term assets

Long-term liabilities

$8.6M

Net cash (debt)

$1.1B

Net cash / market cap

12.37%

Net cash growth

117.51%

Net debt / equity

-1.04

Piotroski F-Score

Shareholders' equity

$1.1B

Tangible book value

$954.7M

Tangible book value per share

$10.84

Total assets

$1.2B

Total cash

$1.1B

Total debt

Total liabilities

$71.9M

WACC

21.34%

Metric	Value
Current assets	$1.2B
Current liabilities	$63.3M
Current ratio	18.53
Net working capital	$-35.6M
Quick ratio	18.23
Working capital	$1.1B

Metric

Value

Current assets

$1.2B

Current liabilities

$63.3M

Current ratio

18.53

Net working capital

$-35.6M

Quick ratio

18.23

Working capital

$1.1B

Metric	Value
Buyback yield / dilution	-31.8%
Dividend yield	0%
Shareholder yield	-31.8%

Metric

Value

Buyback yield / dilution

-31.8%

Dividend yield

Shareholder yield

-31.8%

Metric	Value
10Y price change	-32.93%
10Y return CAGR	-3.92%
10Y total return	-32.93%
150-day SMA	$84.13
1D price change	0.42%
1M price change	14.96%
1M total return	14.96%
1W price change	7.78%
1W total return	7.78%
1Y price change	300.94%
1Y return CAGR	301.32%
1Y total return	300.94%
20-day SMA	$87.48
200-day SMA	$72.56
3M price change	-1.53%
3M total return	-1.53%
3Y price change	824.11%
3Y return CAGR	109.81%
3Y total return	824.11%
50-day SMA	$90.46
50-day SMA vs 200-day SMA	50over200
52-week high	$110.18
52-week high date	2026-08-19
52-week low	$21.15
52-week low date	2025-11-07
5Y price change	-47.18%
5Y return CAGR	-11.99%
5Y total return	-47.18%
6M price change	37.01%
6M total return	37.01%
All-time high	$318.75
All-time high date	2016-04-08
All-time low	$2.66
All-time low date	2023-06-21
Average true range (ATR)	$4.82
Average volume	1.4M
Beta (1Y)	2.28
Beta (2Y)	1.92
Beta (5Y)	3.11
Change from 52-week high	-9.72%
Change from 52-week low	370.4%
Change from all-time high	-69.09%
Change from all-time low	3,603.38%
Change from open	0.28%
Day's gap	0.14%
Dollar volume	$58.7M
High price	$100.00
Low price	$98.03
Monthly RSI	76.98
Open price	$99.19
Position in 52-week range	72.84%
Premarket change	-0.01%
Premarket close	$99.05
Premarket price	$99.04
Previous close	$99.05
Price vs 150-day SMA	17.1%
Price vs 20-day SMA	12.61%
Price vs 200-day SMA	35.76%
Price vs 50-day SMA	8.9%
Relative volume	0.42
RSI	63.28
Sharpe ratio	2.37
Sharpe ratio (3Y)	1.25
Sharpe ratio (5Y)	0.42
Sortino ratio	4.34
Sortino ratio (3Y)	2.07
Sortino ratio (5Y)	1.14
Volume	590.1K
Weekly RSI	62.07
YTD price change	200.7%
YTD total return	200.7%

Metric

Value

10Y price change

-32.93%

10Y return CAGR

-3.92%

10Y total return

-32.93%

150-day SMA

$84.13

1D price change

0.42%

1M price change

14.96%

1M total return

14.96%

1W price change

7.78%

1W total return

7.78%

1Y price change

300.94%

1Y return CAGR

301.32%

1Y total return

300.94%

20-day SMA

$87.48

200-day SMA

$72.56

3M price change

-1.53%

3M total return

-1.53%

3Y price change

824.11%

3Y return CAGR

109.81%

3Y total return

824.11%

50-day SMA

$90.46

50-day SMA vs 200-day SMA

50over200

52-week high

$110.18

52-week high date

2026-08-19

52-week low

$21.15

52-week low date

2025-11-07

5Y price change

-47.18%

5Y return CAGR

-11.99%

5Y total return

-47.18%

6M price change

37.01%

6M total return

37.01%

All-time high

$318.75

All-time high date

2016-04-08

All-time low

$2.66

All-time low date

2023-06-21

Average true range (ATR)

$4.82

Average volume

1.4M

Beta (1Y)

2.28

Beta (2Y)

1.92

Beta (5Y)

3.11

Change from 52-week high

-9.72%

Change from 52-week low

370.4%

Change from all-time high

-69.09%

Change from all-time low

3,603.38%

Change from open

0.28%

Day's gap

0.14%

Dollar volume

$58.7M

High price

$100.00

Low price

$98.03

Monthly RSI

76.98

Open price

$99.19

Position in 52-week range

72.84%

Premarket change

-0.01%

Premarket close

$99.05

Premarket price

$99.04

Previous close

$99.05

Price vs 150-day SMA

17.1%

Price vs 20-day SMA

12.61%

Price vs 200-day SMA

35.76%

Price vs 50-day SMA

8.9%

Relative volume

0.42

RSI

63.28

Sharpe ratio

2.37

Sharpe ratio (3Y)

1.25

Sharpe ratio (5Y)

0.42

Sortino ratio

4.34

Sortino ratio (3Y)

2.07

Sortino ratio (5Y)

1.14

Volume

590.1K

Weekly RSI

62.07

YTD price change

200.7%

YTD total return

200.7%

Metric	Value
Float	87.4M
Float percentage	93.56%
Shares change (QoQ)	7.87%
Shares change (YoY)	31.8%
Shares held by insiders	5.38%
Shares held by institutions	105.94%
Shares outstanding	93.5M
Short % of float	14.69%
Short % of shares	13.74%
Short ratio	9.9 days

Metric

Value

Float

87.4M

Float percentage

93.56%

Shares change (QoQ)

7.87%

Shares change (YoY)

31.8%

Shares held by insiders

5.38%

Shares held by institutions

105.94%

Shares outstanding

93.5M

Short % of float

14.69%

Short % of shares

13.74%

Short ratio

9.9 days

Spyre Therapeutics, Inc. (SYRE)

Price

Financial snapshot

Fair-value bridge

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Profile and market data

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