Healthcare / BiotechnologyUpdated 2026-05-10 22:07 UTC

SEPN stock hub

Septerna, Inc. has a live ticker hub with the latest available market, valuation, profitability, growth, ownership, and risk indicators.

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Fair value midpoint

n/a

Fair value pending

Upside to midpoint

n/a

Based on latest report

Confidence

n/a

Data quality and model convergence

Market cap

1.1B

NASDAQ

Market data

Live price

Current market quote for this ticker.

Current price

SEPN

In the news

Latest news · SEPN

Recent company headlines from major financial publishers.

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Fetching the latest headlines.

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Fetching the latest headlines.

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Fetching the latest headlines.

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector context

Where the current metrics sit

Percentiles come from the backend screener cohort cache for the ticker's country and sector.

Forward P/En/a

P25 12.3P50 18.4P75 33.1

Trailing P/En/a

P25 14.9P50 23.2P75 38.5

ROE-12.2

P25 -105.6P50 -46.5P75 -3.1

ROIC-148.2

P25 -63.1P50 -27.3P75 0.5

Benchmarks - 1M

S&P 500n/a

Nasdaq Compositen/a

Dow Jones Industrial Averagen/a

Russell 2000n/a

Indicator catalog

All SEPN market and fundamental indicators

A searchable catalog of the available market, valuation, profitability, growth, balance-sheet, ownership, and analyst metrics for this ticker.

Available fields

202

Groups with data

Currency

USD

Showing 202 of 202 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Cik	0001984086
Company name	Septerna, Inc.
Country	United States
Country code	US
Cusip	81734D104
Employees	130
Employees Change	55%
Employees Change Percent	73.33
Enterprise value	$546.9M
Exchange	NASDAQ
Financial currency	USD
First seen	2026-05-09
Industry	Biotechnology
IPO Date	2024-10-25
Isin	US81734D1046
Last refreshed	2026-05-10
Market cap	$1.1B
Market cap category	Small-Cap
Price	$23.87
Price currency	USD
Rev Per Employee	353,469.23x
Sector	Healthcare
Sic	2834
Symbol	SEPN
Website	https://septerna.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings Yield	-4.56%
EV Sales Forward	6.36x
EV/FCF	4.99x
EV/Sales	11.9x
FCF yield	10.23%
P/B ratio	2.8x
P/S ratio	23.33x
PS Forward	12.47x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
EBIT Margin	-175.83%
EBITDA Margin	-172.34%
FCF margin	238.67%
Gross margin	100%
Gross Profit	$46M
Gross Profit Growth	4,174.51%
Gross Profit Growth Q	11,276.42%
Net Income	$-48.9M
Net Income Growth Quarters	2%
Net Income Growth Years	1%
Pretax Margin	-106.35%
Profit Margin	-106.37%
Profit Per Employee	$-375,992
ROA	-9.59
ROCE	-15.87
ROE	-12.19
ROIC	-148.2

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
Cagr1y	238.87%
EPS Growth Years	1
Revenue Growth	4,174.51x
Revenue Growth Q	11,276.42x
Revenue Growth Quarters	2x
Revenue Growth Years	2x

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Asset Turnover	$0.09
Assets	$596.2M
Cash	$391.1M
Current Assets	$411M
Current Liabilities	$86.9M
Debt	$23.6M
Debt Equity	$0.06
Debt FCF	$0.22
Equity	$381.9M
Liabilities	$214.3M
Long Term Assets	$185.2M
Long Term Liabilities	$127.3M
Net Cash	$525M
Net Cash By Market Cap	$48.98
Net Cash Growth	32.81%
Net Debt Equity	$-1.37
Net Debt FCF	$-4.79
Tangible Book Value	$381.9M
Tangible Book Value Per Share	$8.52

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Current ratio	4.73
Net Working Capital	$-64.8M
Quick ratio	4.66
Working Capital	$324M
Working Capital Turnover	$0.14

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback Yield	-347.46%
Dividend Yield	0%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
1Y total return	238.58%
200-day SMA	22.24
50-day SMA	25.24
50-day SMA vs 200-day SMA	50over200
All Time High	32.63
All Time High Change	-26.85%
All Time High Date	2026-02-25
All Time Low	4.17
All Time Low Change	472.42%
All Time Low Date	2025-02-18
ATR	1.49
Beta1y	2.1
Beta2y	2.17
Ch YTD	-14.38
High	24.86
High52	32.63
High52 Date	2026-02-25
High52ch	-26.85%
Low	23.82
Low52	6.44
Low52 Date	2025-05-13
Low52ch	270.65%
Ma50ch	-5.43%
Price vs 200-day SMA	7.32%
RSI	45.29
RSI Monthly	49.02
RSI Weekly	49.68
Sharpe ratio	1.84x
Sortino ratio	4.4
Total Return	-347.46%
Tr YTD	-14.38
Tr1m	-3.9%
Tr1w	1.1%
Tr3m	-6.06%

Analyst estimates

Ratings, targets, revisions, and forward estimate fields.

Metric	Value
Analyst Count	7
Analyst Count Top	5
Analyst Price Target Top	$36.8
Analyst Ratings	Strong Buy
Analyst Ratings Top	Strong Buy
Earnings EPS Estimate	$-0.32
Earnings Revenue Estimate	16,061,112x
Earnings Revenue Estimate Growth	7,233.84x
Operating Income	$-80.8M
Operating margin	-175.8
Price target	$38.14
Price Target Change	$59.78
Price Target Change Top	$54.17

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	22,896,296%
Float Percent	50.99%
Shares Insiders	3.2%
Shares Institutions	57.31%
Shares Out	44,906,374
Shares Qo Q	-2.24%
Shares Yo Y	347.46%
Short Float	10.73%
Short Ratio	8.85
Short Shares	5.47

Other indicators

Additional ticker metrics that do not fit the primary research groupings yet.

Metric	Value
Adjusted FCF	$101.2M
Average Volume	353,657.8x
Bv Per Share	8.52
CAPEX	$-518,000
Ch1m	-3.9
Ch1w	1.1
Ch1y	238.6
Ch3m	-6.06
Ch6m	28.96
Change	-0.46%
Change From Open	-0.46
Close	23.98
Days Gap	0
Depreciation Amortization	1,604,000
Dollar Volume	4,973,648.7
Earnings Date	2026-05-11
Earnings Time	bmo
EBIT	$-80.8M
EBITDA	$-79.2M
EPS	$-1.1
F Score	3
FCF	$109.7M
FCF EV Yield	20.05x
FCF Per Share	$2.44
Financing CF	1,689,000
Fiscal Year End	December
Founded	2,022
Income Tax	$12,000
Investing CF	-229,352,000
Ipr	32.61
Iprfo	1.57
Is Primary Listing	1
Is Spac	No
Last Earnings Date	2026-03-09
Last Report Date	2025-12-31
Last Split Type	Never
Last10k Filing Date	2026-03-09
Ma150	25.06
Ma150ch	-4.75%
Ma20	24.72
Ma20ch	-3.44%
Net CF	-117,474,000
Next Earnings Date	2026-05-22
Open	23.98
Optionable	Yes
P FCF Ratio	9.77
P OCF Ratio	9.73
Position In Range	4.81
Post Close	23.87
Postmarket Change Percent	-0.04
Postmarket Price	$23.86
Ppne	25,933,000
Price Date	2026-05-08
Ptbv Ratio	2.81
Relative Volume	0.59x
Revenue	45,951,000x
SBC By Revenue	18.45x
Share Based Comp	8,476,000
Tax By Revenue	0.03x
Tr6m	28.96%
Us State	California
Volume	208,364
Z Score	1.67

Fast facts

Decision checkpoints

A compact product layer over the same report payload.

Risk gate

n/a

Named kill scenarios are reviewed before any bullish rating can stand.

Moat score

n/a

Business quality stays separate from stock attractiveness.

Forward P/E

n/a

Valuation uses the full report model stack, not a single multiple.

Next action

Research pending

Final action steps are kept in the recommendation tab.

Income

Does SEPN pay a dividend?

Capital-return profile for this ticker.

Performance

SEPN stock returns vs the market

Total return (incl. dividends) compared to S&P 500.

Ownership

Who owns SEPN?

Insider, institutional, and short-interest positioning.

Institutional ownership

+57.3%

Float: +51.0% of shares outstanding

Insider ownership

+3.2%

Stake held by company insiders. Higher generally signals alignment.

Negative means the company is buying back shares.

Technical

SEPN momentum and risk profile

RSI, moving-average stack, beta, and risk-adjusted return.

RSI (14)

45.3

Neutral momentum band

Price vs 200-day MA

+7.3%

50/200-day relationship not available

Beta (5Y)

n/a

Sensitivity to the broader market

Sharpe ratio

1.84

Risk-adjusted return — higher is better; >1.0 is solid.

Questions

About SEPN

Hub-level FAQ points readers to the deeper analysis pages.

What is the current SEPN stock rating?

Septerna, Inc. is currently shown with the latest rating in the latest report. The hub links directly to the full analysis surface where the rating, fair-value bridge, risks, and scorecard are documented together.

Where can I read the full SEPN analysis?

The full report lives at /stocks/SEPN/analysis. The bare ticker page is a product hub that summarizes the latest read and sends readers into the relocated analysis tabs without making the analysis surface depend on the hub.

What fair-value range is used for SEPN?

The latest report frames SEPN around the latest fair-value range. Treat that range as the entry point, then check the valuation, sensitivity, and bear-case tabs before making an investment decision.

How often is the SEPN page updated?

The hub updates with the latest published stock report and live backend market data. The analysis pages remain reachable under /analysis, so a hub rollback does not remove the report reader.