Healthcare / BiotechnologyUpdated 2026-05-10 22:07 UTC

IONS stock hub

Ionis Pharmaceuticals, Inc. has a live ticker hub with the latest available market, valuation, profitability, growth, ownership, and risk indicators.

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Fair value midpoint

n/a

Fair value pending

Upside to midpoint

n/a

Based on latest report

Confidence

n/a

Data quality and model convergence

Market cap

12.5B

NASDAQ

Market data

Live price

Current market quote for this ticker.

Current price

IONS

In the news

Latest news · IONS

Recent company headlines from major financial publishers.

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Fetching the latest headlines.

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Fetching the latest headlines.

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Fetching the latest headlines.

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector context

Where the current metrics sit

Percentiles come from the backend screener cohort cache for the ticker's country and sector.

Forward P/En/a

P25 12.3P50 18.4P75 33.1

Trailing P/En/a

P25 14.9P50 23.2P75 38.5

ROE-67.6

P25 -105.6P50 -46.5P75 -3.1

ROIC-45.5

P25 -63.1P50 -27.3P75 0.5

Benchmarks - 1M

S&P 500n/a

Nasdaq Compositen/a

Dow Jones Industrial Averagen/a

Russell 2000n/a

Indicator catalog

All IONS market and fundamental indicators

A searchable catalog of the available market, valuation, profitability, growth, balance-sheet, ownership, and analyst metrics for this ticker.

Available fields

220

Groups with data

Currency

USD

Showing 220 of 220 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Cik	0000874015
Company name	Ionis Pharmaceuticals, Inc.
Country	United States
Country code	US
Cusip	462222100
Employees	1,402
Employees Change	333%
Employees Change Percent	31.15
Enterprise value	$13.1B
Exchange	NASDAQ
Financial currency	USD
First seen	2026-05-09
Industry	Biotechnology
IPO Date	1991-05-17
Isin	US4622221004
Last refreshed	2026-05-10
Market cap	$12.5B
Market cap category	Large-Cap
Price	$75.71
Price currency	USD
Rev Per Employee	754,771.75x
Sector	Healthcare
Sic	2834
Symbol	IONS
Website	https://www.ionis.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings Yield	-2.61%
EV Sales Forward	14.28x
EV/Sales	12.42x
FCF yield	-7.76%
P/B ratio	25.56x
P/S ratio	11.82x
PS Forward	13.59x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
EBIT Margin	-33.29%
EBITDA Margin	-32%
Gross margin	10.94%
Gross Profit	$115.7M
Gross Profit Growth5 Y	-5.1%
Net Income	$-327M
Net Income Growth Quarters	1%
Net Income Growth Years	1%
Pretax Margin	-30.72%
Profit Margin	-30.9%
Profit Per Employee	$-233,222
ROA	-7.03
Roa5y	-7.19
ROCE	-12.89
ROE	-67.62
Roe5y	-56.83
ROIC	-45.5

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
Cagr10y	8.33%
Cagr15y	15.66%
Cagr1y	129.07%
Cagr20y	11.52%
Cagr3y	27.88%
Cagr5y	15.69%
EPS Growth Quarters	1
EPS Growth Years	1
Revenue Growth	47.53x
Revenue Growth Q	86.98x
Revenue Growth Quarters	1x
Revenue Growth Years	1x
Revenue Growth3 Y	22.48x
Revenue Growth5 Y	8.38x

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Asset Turnover	$0.34
Assets	$3.4B
Cash	$2B
Current Assets	$2.9B
Current Liabilities	$716.6M
Debt	$2.6B
Debt Equity	$5.31
Equity	$491.4M
Interest Coverage	-3.91
Liabilities	$3B
Long Term Assets	$513M
Long Term Liabilities	$2.2B
Net Cash	$-632.6M
Net Cash By Market Cap	$-5.06
Net Debt Equity	$1.29
Tangible Book Value	$491.4M
Tangible Book Value Per Share	$2.96
WACC	5.73

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Current ratio	4.1
Inventory Turnover	110.5
Net Working Capital	$686.7M
Quick ratio	2.86
Working Capital	$2.2B
Working Capital Turnover	$0.48

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback Yield	-5.71%
Dividend Yield	0%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
10Y total return	122.61%
1Y total return	128.94%
200-day SMA	70.54
3Y total return	109.14%
50-day SMA	74.6
50-day SMA vs 200-day SMA	50over200
5Y total return	107.2%
All Time High	86.74
All Time High Change	-12.72%
All Time High Date	2026-02-05
All Time Low	2.5
All Time Low Change	2,928.4%
All Time Low Date	2003-03-17
ATR	2.37
Beta	0.38
Beta1y	0.74
Beta2y	0.75
Ch YTD	-4.3
High	77.4
High52	86.74
High52 Date	2026-02-05
High52ch	-12.72%
Low	75.24
Low52	31.66
Low52 Date	2025-05-08
Low52ch	139.14%
Ma50ch	1.49%
Premarket Change Percent	-0.28
Premarket Price	$75.81
Price vs 200-day SMA	7.32%
RSI	53.25
RSI Monthly	67.23
RSI Weekly	53.99
Sharpe ratio	1.89x
Sortino ratio	4.77
Total Return	-5.71%
Tr YTD	-4.3
Tr15y	786.53%
Tr1m	2.46%
Tr1w	0.57%
Tr3m	-12.47%

Analyst estimates

Ratings, targets, revisions, and forward estimate fields.

Metric	Value
Analyst Count	22
Analyst Count Top	9
Analyst Price Target Top	$102
Analyst Ratings	Strong Buy
Analyst Ratings Top	Strong Buy
Earnings EPS Estimate	$-0.8
Earnings Revenue Estimate	194,893,768x
Earnings Revenue Estimate Growth	47.65x
Operating Income	$-352.2M
Operating margin	-33.29
Price target	$94
Price Target Change	$24.16
Price Target Change Top	$34.58

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	163,979,405%
Float Percent	99.22%
Net Borrowing	502,183,000
Shares Insiders	0.74%
Shares Institutions	104.19%
Shares Out	165,262,556
Shares Qo Q	1.77%
Shares Yo Y	5.71%
Short Float	8.39%
Short Ratio	6.89
Short Shares	8.33

Other indicators

Additional ticker metrics that do not fit the primary research groupings yet.

Metric	Value
Adjusted FCF	$-1.1B
Average Volume	1,803,117x
Bv Per Share	2.96
CAPEX	$-60.6M
Ch10y	122.6
Ch15y	786.5
Ch1m	2.46
Ch1w	0.57
Ch1y	128.9
Ch20y	785.5
Ch3m	-12.47
Ch3y	109.1
Ch5y	107.2
Ch6m	2.94
Change	-0.41%
Change From Open	-0.97
Close	76.02
Days Gap	0.57
Depreciation Amortization	13,599,000
Dollar Volume	125,393,324.7
Earnings Date	2026-04-29
Earnings Time	bmo
EBIT	$-352.2M
EBITDA	$-338.6M
EPS	$-2.02
F Score	2
FCF	$-971.3M
FCF EV Yield	-7.39x
FCF Per Share	$-5.88
Financing CF	730,899,000
Fiscal Year End	December
Founded	1,989
Income Tax	$1.9M
Investing CF	88,585,000
Is Primary Listing	1
Is Spac	No
Last Earnings Date	2026-04-29
Last Report Date	2026-03-31
Last Split Type	Never
Last10k Filing Date	2026-02-26
Ma150	76.82
Ma150ch	-1.45%
Ma20	74.98
Ma20ch	0.98%
Net CF	-90,811,000
Next Earnings Date	2026-07-29
Open	76.45
Optionable	Yes
Position In Range	21.76
Post Close	75.71
Postmarket Change Percent	0.12
Postmarket Price	$75.8
Ppne	377,465,000
Pre Close	76.02
Price Date	2026-05-08
Ptbv Ratio	25.46
Relative Volume	0.92x
Revenue	1,058,190,000x
SBC By Revenue	13.93x
Share Based Comp	147,431,000
Tax By Revenue	0.18x
Tr20y	785.5%
Tr6m	2.94%
Us State	California
Volume	1,656,232
Z Score	1.56

Fast facts

Decision checkpoints

A compact product layer over the same report payload.

Risk gate

n/a

Named kill scenarios are reviewed before any bullish rating can stand.

Moat score

n/a

Business quality stays separate from stock attractiveness.

Forward P/E

n/a

Valuation uses the full report model stack, not a single multiple.

Next action

Research pending

Final action steps are kept in the recommendation tab.

Income

Does IONS pay a dividend?

Capital-return profile for this ticker.

Performance

IONS stock returns vs the market

Total return (incl. dividends) compared to S&P 500.

Ownership

Who owns IONS?

Insider, institutional, and short-interest positioning.

Institutional ownership

+104.2%

Float: +99.2% of shares outstanding

Insider ownership

+0.7%

Stake held by company insiders. Higher generally signals alignment.

Negative means the company is buying back shares.

Technical

IONS momentum and risk profile

RSI, moving-average stack, beta, and risk-adjusted return.

RSI (14)

53.2

Neutral momentum band

Price vs 200-day MA

+7.3%

50/200-day relationship not available

Beta (5Y)

0.38

Less volatile than the market

Sharpe ratio

1.89

Risk-adjusted return — higher is better; >1.0 is solid.

Questions

About IONS

Hub-level FAQ points readers to the deeper analysis pages.

What is the current IONS stock rating?

Ionis Pharmaceuticals, Inc. is currently shown with the latest rating in the latest report. The hub links directly to the full analysis surface where the rating, fair-value bridge, risks, and scorecard are documented together.

Where can I read the full IONS analysis?

The full report lives at /stocks/IONS/analysis. The bare ticker page is a product hub that summarizes the latest read and sends readers into the relocated analysis tabs without making the analysis surface depend on the hub.

What fair-value range is used for IONS?

The latest report frames IONS around the latest fair-value range. Treat that range as the entry point, then check the valuation, sensitivity, and bear-case tabs before making an investment decision.

How often is the IONS page updated?

The hub updates with the latest published stock report and live backend market data. The analysis pages remain reachable under /analysis, so a hub rollback does not remove the report reader.