Healthcare / BiotechnologyUpdated 2026-05-10 22:07 UTC

UPB stock hub

Upstream Bio, Inc. has a live ticker hub with the latest available market, valuation, profitability, growth, ownership, and risk indicators.

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Fair value midpoint

n/a

Fair value pending

Upside to midpoint

n/a

Based on latest report

Confidence

n/a

Data quality and model convergence

Market cap

494.7M

NASDAQ

Market data

Live price

Current market quote for this ticker.

Current price

UPB

In the news

Latest news · UPB

Recent company headlines from major financial publishers.

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Fetching the latest headlines.

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Fetching the latest headlines.

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Fetching the latest headlines.

Calendar

Next earnings

Upcoming earnings date and setup when available.

Upcoming

DateLoading

Window—

EPS estimate—

Revenue estimate—

Sector context

Where the current metrics sit

Percentiles come from the backend screener cohort cache for the ticker's country and sector.

Forward P/En/a

P25 12.3P50 18.4P75 33.1

Trailing P/En/a

P25 14.9P50 23.2P75 38.5

ROE-35.4

P25 -105.6P50 -46.5P75 -3.1

ROIC-24.7

P25 -63.1P50 -27.3P75 0.5

Benchmarks - 1M

S&P 500n/a

Nasdaq Compositen/a

Dow Jones Industrial Averagen/a

Russell 2000n/a

Indicator catalog

All UPB market and fundamental indicators

A searchable catalog of the available market, valuation, profitability, growth, balance-sheet, ownership, and analyst metrics for this ticker.

Available fields

188

Groups with data

Currency

USD

Showing 188 of 188 available metrics for this ticker.

Profile and market data

Ticker identity, listing, currency, market cap, and source dates.

Metric	Value
Cik	0002022626
Company name	Upstream Bio, Inc.
Country	United States
Country code	US
Cusip	91678A107
Employees	75
Enterprise value	$154.4M
Exchange	NASDAQ
Financial currency	USD
First seen	2026-05-09
Industry	Biotechnology
IPO Date	2024-10-11
Isin	US91678A1079
Last refreshed	2026-05-10
Market cap	$494.7M
Market cap category	Small-Cap
Price	$9.09
Price currency	USD
Rev Per Employee	38,053.33x
Sector	Healthcare
Sic	2834
Symbol	UPB
Website	https://upstreambio.com

Valuation

Multiples, yields, enterprise-value ratios, and valuation checks.

Metric	Value
Earnings Yield	-29%
EV Sales Forward	85.33x
EV/Sales	54.11x
FCF yield	-26.98%
P/B ratio	1.45x
P/S ratio	173.33x
PS Forward	273.31x

Profitability

Margins, returns on capital, cash conversion, and quality metrics.

Metric	Value
Gross margin	100%
Gross Profit	$2.9M
Gross Profit Growth	20.42%
Gross Profit Growth Q	8.97%
Net Income	$-143.4M
Net Income Growth Years	0%
Pretax Margin	-5,026.03%
Profit Per Employee	$-1.9M
ROA	-23.99
ROCE	-47.12
ROE	-35.43
ROIC	-24.66

Growth

Revenue, earnings, cash-flow, and forward growth indicators.

Metric	Value
Cagr1y	5.95%
EPS Growth Years	2
Revenue Growth	20.42x
Revenue Growth Q	8.97x
Revenue Growth Quarters	3x
Revenue Growth Years	1x

Financial strength

Debt, cash, solvency, accounting-quality, and balance-sheet signals.

Metric	Value
Asset Turnover	$0.01
Assets	$353.8M
Cash	$341.5M
Current Assets	$351.8M
Current Liabilities	$13.5M
Debt	$1.3M
Debt Equity	$0
Equity	$339.8M
Liabilities	$14M
Long Term Assets	$2M
Long Term Liabilities	$549,000
Net Cash	$340.2M
Net Cash By Market Cap	$68.78
Net Cash Growth	-27.39%
Net Debt Equity	$-1
Tangible Book Value	$339.8M
Tangible Book Value Per Share	$6.26

Liquidity

Current-asset coverage and working-capital efficiency metrics.

Metric	Value
Current ratio	26.15
Net Working Capital	$-2.4M
Quick ratio	25.56
Working Capital	$338.3M
Working Capital Turnover	$0.01

Dividends and buybacks

Dividend yield, payout, buybacks, and shareholder-yield indicators.

Metric	Value
Buyback Yield	-293.59%
Dividend Yield	0%

Performance and technicals

Returns, volatility, beta, momentum, RSI, and moving-average context.

Metric	Value
1Y total return	5.94%
200-day SMA	18.83
50-day SMA	9.15
50-day SMA vs 200-day SMA	50under200
All Time High	33.68
All Time High Change	-73.01%
All Time High Date	2026-01-14
All Time Low	5.14
All Time Low Change	76.85%
All Time Low Date	2025-04-09
ATR	0.54
Beta1y	1.21
Beta2y	1.08
Ch YTD	-66.52
High	9.35
High52	33.68
High52 Date	2026-01-14
High52ch	-73.01%
Low	8.8
Low52	7.25
Low52 Date	2026-03-03
Low52ch	25.38%
Ma50ch	-0.61%
Price vs 200-day SMA	-51.73%
RSI	42.04
RSI Monthly	36.29
RSI Weekly	35.11
Sharpe ratio	0.55x
Sortino ratio	0.76
Total Return	-293.59%
Tr YTD	-66.52
Tr1m	-6.29%
Tr1w	-3.3%
Tr3m	-65.31%

Analyst estimates

Ratings, targets, revisions, and forward estimate fields.

Metric	Value
Analyst Count	3
Analyst Count Top	1
Analyst Price Target Top	$15
Analyst Ratings	Buy
Analyst Ratings Top	Hold
Earnings EPS Estimate	$-0.76
Earnings Revenue Estimate	379,736x
Earnings Revenue Estimate Growth	-32.91x
Operating Income	$-160.4M
Operating margin	-5,618.8
Price target	$37.67
Price Target Change	$314
Price Target Change Top	$65.02

Ownership and float

Institutional, insider, float, short-interest, and share-count fields.

Metric	Value
Float	34,587,462%
Float Percent	63.56%
Shares Insiders	0.29%
Shares Institutions	75.17%
Shares Out	54,419,986
Shares Qo Q	0.29%
Shares Yo Y	293.59%
Short Float	8.74%
Short Ratio	3.73
Short Shares	5.55

Other indicators

Additional ticker metrics that do not fit the primary research groupings yet.

Metric	Value
Adjusted FCF	$-143.8M
Average Volume	504,523.5x
Bv Per Share	6.26
CAPEX	$-165,000
Ch1m	-6.29
Ch1w	-3.3
Ch1y	5.94
Ch3m	-65.31
Ch6m	-60.41
Change	1.11%
Change From Open	2.36
Close	8.99
Days Gap	-1.22
Depreciation Amortization	188,000
Dollar Volume	4,146,339.9
Earnings Date	2026-05-22
Earnings Time	bmo
EBIT	$-160.4M
EBITDA	$-160.2M
EPS	$-2.66
F Score	1
FCF	$-133.4M
FCF EV Yield	-86.4x
FCF Per Share	$-2.45
Financing CF	2,441,000
Fiscal Year End	December
Founded	2,021
Investing CF	-93,480,000
Ipr	-46.53
Iprfo	-57.72
Is Primary Listing	1
Is Spac	No
Last Earnings Date	2026-03-26
Last Report Date	2025-12-31
Last Split Type	Never
Last10k Filing Date	2026-03-26
Ma150	19.42
Ma150ch	-53.19%
Ma20	9.53
Ma20ch	-4.62%
Net CF	-224,314,000
Next Earnings Date	2026-05-22
Open	8.88
Optionable	Yes
Position In Range	52.73
Post Close	9.09
Postmarket Change Percent	1.21
Postmarket Price	$9.2
Ppne	1,781,000
Price Date	2026-05-08
Ptbv Ratio	1.46
Relative Volume	0.9x
Revenue	2,854,000x
SBC By Revenue	362.02x
Share Based Comp	10,332,000
Tr6m	-60.41%
Us State	Massachusetts
Volume	456,143
Z Score	32.81

Fast facts

Decision checkpoints

A compact product layer over the same report payload.

Risk gate

n/a

Named kill scenarios are reviewed before any bullish rating can stand.

Moat score

n/a

Business quality stays separate from stock attractiveness.

Forward P/E

n/a

Valuation uses the full report model stack, not a single multiple.

Next action

Research pending

Final action steps are kept in the recommendation tab.

Income

Does UPB pay a dividend?

Capital-return profile for this ticker.

Performance

UPB stock returns vs the market

Total return (incl. dividends) compared to S&P 500.

Ownership

Who owns UPB?

Insider, institutional, and short-interest positioning.

Institutional ownership

+75.2%

Float: +63.6% of shares outstanding

Insider ownership

+0.3%

Stake held by company insiders. Higher generally signals alignment.

Negative means the company is buying back shares.

Technical

UPB momentum and risk profile

RSI, moving-average stack, beta, and risk-adjusted return.

RSI (14)

42.0

Neutral momentum band

Price vs 200-day MA

-51.7%

50/200-day relationship not available

Beta (5Y)

n/a

Sensitivity to the broader market

Sharpe ratio

0.55

Risk-adjusted return — higher is better; >1.0 is solid.

Questions

About UPB

Hub-level FAQ points readers to the deeper analysis pages.

What is the current UPB stock rating?

Upstream Bio, Inc. is currently shown with the latest rating in the latest report. The hub links directly to the full analysis surface where the rating, fair-value bridge, risks, and scorecard are documented together.

Where can I read the full UPB analysis?

The full report lives at /stocks/UPB/analysis. The bare ticker page is a product hub that summarizes the latest read and sends readers into the relocated analysis tabs without making the analysis surface depend on the hub.

What fair-value range is used for UPB?

The latest report frames UPB around the latest fair-value range. Treat that range as the entry point, then check the valuation, sensitivity, and bear-case tabs before making an investment decision.

How often is the UPB page updated?

The hub updates with the latest published stock report and live backend market data. The analysis pages remain reachable under /analysis, so a hub rollback does not remove the report reader.