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Septerna, Inc. (SEPN)

NASDAQ: SEPN · USD

$43.8

-0.38 (-0.9%)· Recorded snapshot

Market cap	2B
Revenue (ttm)	98.9M
Net income (ttm)	-24.2M
EPS (ttm)	-$0.54
Shares out	46.7M
Volume	329,839
Beta	2.28

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Revenue (ttm): 98.9M
Net income (ttm): -24.2M
EPS (ttm): -$0.54
Market cap: 2B

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	Hold

Metric	Value
Amount currency	USD
CIK code	0001984086
Company name	Septerna, Inc.
Country	United States
Country code	US
CUSIP number	81734D104
Earnings date	2026-11-09
Earnings time	bmo
Employees	123
Enterprise value	$1.5B
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	2022
In index	RUSSELL2000
Industry	Biotechnology
IPO date	2024-10-25
Is primary listing	Yes
Is SPAC	No
ISIN number	US81734D1046
Last 10-K release date	2026-03-09
Last earnings date	2026-08-10
Last refreshed	2026-10-28
Last stock split type	Never
Market cap	$2B
Market cap category	Mid-Cap
Next earnings date	2026-11-09
Options	Yes
Price	$43.76
Price currency	USD
Sector	Healthcare
SIC code	2834
Stock price date	2026-10-28
Symbol	SEPN
U.S. state	California
Website	https://www.septerna.com

Metric

Value

Amount currency

USD

CIK code

0001984086

Company name

Septerna, Inc.

Country

United States

Country code

CUSIP number

81734D104

Earnings date

2026-11-09

Earnings time

bmo

Employees

123

Enterprise value

$1.5B

Exchange

NASDAQ

Financial currency

USD

Financial report date

2026-06-30

First seen

2026-05-09

Fiscal year end

December

Founded

2022

In index

RUSSELL2000

Industry

Biotechnology

IPO date

2024-10-25

Is primary listing

Yes

Is SPAC

ISIN number

US81734D1046

Last 10-K release date

2026-03-09

Last earnings date

2026-08-10

Last refreshed

2026-10-28

Last stock split type

Never

Market cap

$2B

Market cap category

Mid-Cap

Next earnings date

2026-11-09

Options

Yes

Price

$43.76

Price currency

USD

Sector

Healthcare

SIC code

2834

Stock price date

2026-10-28

Symbol

SEPN

U.S. state

California

Website

https://www.septerna.com

Metric	Value
Earnings yield	-1.24%
EV/FCF	15.1x
EV/Sales	16.05x
FCF / EV yield	6.62%
FCF yield	5.05%
Forward EV/Sales	19.83x
Forward P/S	26.01x
P/(FCF - SBC) ratio	23.43x
P/(OCF - SBC) ratio	23.2x
P/B ratio	5.21x
P/FCF ratio	19.8x
P/OCF ratio	19.63x
P/S ratio	21.05x
Price / tangible book value	5.38x
Sector forward P/E	23.56x
Sector P/E	50.13x

Metric

Value

Earnings yield

-1.24%

EV/FCF

15.1x

EV/Sales

16.05x

FCF / EV yield

6.62%

FCF yield

5.05%

Forward EV/Sales

19.83x

Forward P/S

26.01x

P/(FCF - SBC) ratio

23.43x

P/(OCF - SBC) ratio

23.2x

P/B ratio

5.21x

P/FCF ratio

19.8x

P/OCF ratio

19.63x

P/S ratio

21.05x

Price / tangible book value

5.38x

Sector forward P/E

23.56x

Sector P/E

50.13x

Metric	Value
EBIT margin	-56.68%
EBITDA margin	-55.01%
FCF margin	106.29%
Gross margin	100%
Operating margin	-56.68%
Pretax margin	-23.17%
Profit margin	-24.51%
Profit per employee	$-197,041
Revenue per employee	$803,919
ROA	-7.13%
ROCE	-11.5%
ROE	-6.34%
ROIC	-123.05%
SBC / revenue	16.46%
Tax / revenue	1.34%

Metric

Value

EBIT margin

-56.68%

EBITDA margin

-55.01%

FCF margin

106.29%

Gross margin

100%

Operating margin

-56.68%

Pretax margin

-23.17%

Profit margin

-24.51%

Profit per employee

$-197,041

Revenue per employee

$803,919

ROA

-7.13%

ROCE

-11.5%

ROE

-6.34%

ROIC

-123.05%

SBC / revenue

16.46%

Tax / revenue

1.34%

Metric	Value
EPS growth quarters	2
EPS growth years	1
Gross profit growth	13,520.11%
Gross profit growth (Q)	22,375.63%
Net income growth quarters	4
Net income growth years	1
Revenue growth	13,520.11%
Revenue growth (Q)	22,375.63%
Revenue growth (QoQ)	0.84%
Revenue growth quarters	4
Revenue growth years	2

Metric

Value

EPS growth quarters

EPS growth years

Gross profit growth

13,520.11%

Gross profit growth (Q)

22,375.63%

Net income growth quarters

Net income growth years

Revenue growth

13,520.11%

Revenue growth (Q)

22,375.63%

Revenue growth (QoQ)

0.84%

Revenue growth quarters

Revenue growth years

Metric	Value
Capital expenditures	$-910,000
Depreciation and amortization	$1.7M
EBIT	$-56M
EBITDA	$-54.4M
EPS	$-0.54
FCF per share	$2.25
Financing cash flow	$18.4M
Free cash flow	$105.1M
Free cash flow minus SBC	$88.8M
Gross profit	$98.9M
Income taxes	$1.3M
Investing cash flow	$-229.1M
Net cash flow	$-104.6M
Net income	$-24.2M
Operating cash flow minus SBC	$89.7M
Operating income	$-56M
Revenue	$98.9M
Stock-based compensation	$16.3M

Metric

Value

Capital expenditures

$-910,000

Depreciation and amortization

$1.7M

EBIT

$-56M

EBITDA

$-54.4M

EPS

$-0.54

FCF per share

$2.25

Financing cash flow

$18.4M

Free cash flow

$105.1M

Free cash flow minus SBC

$88.8M

Gross profit

$98.9M

Income taxes

$1.3M

Investing cash flow

$-229.1M

Net cash flow

$-104.6M

Net income

$-24.2M

Operating cash flow minus SBC

$89.7M

Operating income

$-56M

Revenue

$98.9M

Stock-based compensation

$16.3M

Metric	Value
Altman Z-Score	3.46
Book value per share	$8.47
Debt / equity	0.06
Debt / FCF	0.21
Long-term assets	$170.6M
Long-term liabilities	$100.7M
Net cash (debt)	$494M
Net cash / market cap	23.73%
Net cash growth	39.29%
Net debt / equity	-1.28
Net debt / FCF	-4.7
Piotroski F-Score	3
Property, plant and equipment	$24.3M
Shareholders' equity	$386.7M
Tangible book value	$386.7M
Tangible book value per share	$8.47
Total assets	$566.7M
Total cash	$372.3M
Total debt	$22.5M
Total liabilities	$180M
WACC	16.62%

Metric

Value

Altman Z-Score

3.46

Book value per share

$8.47

Debt / equity

0.06

Debt / FCF

0.21

Long-term assets

$170.6M

Long-term liabilities

$100.7M

Net cash (debt)

$494M

Net cash / market cap

23.73%

Net cash growth

39.29%

Net debt / equity

-1.28

Net debt / FCF

-4.7

Piotroski F-Score

Property, plant and equipment

$24.3M

Shareholders' equity

$386.7M

Tangible book value

$386.7M

Tangible book value per share

$8.47

Total assets

$566.7M

Total cash

$372.3M

Total debt

$22.5M

Total liabilities

$180M

WACC

16.62%

Metric	Value
Asset turnover	0.2
Current assets	$396.2M
Current liabilities	$79.3M
Current ratio	4.99
Net working capital	$-53.1M
Quick ratio	4.9
Working capital	$316.8M
Working capital turnover	0.31

Metric

Value

Asset turnover

0.2

Current assets

$396.2M

Current liabilities

$79.3M

Current ratio

4.99

Net working capital

$-53.1M

Quick ratio

4.9

Working capital

$316.8M

Working capital turnover

0.31

Metric	Value
Buyback yield / dilution	-45.19%
Dividend yield	0%
Shareholder yield	-45.19%

Metric

Value

Buyback yield / dilution

-45.19%

Dividend yield

Shareholder yield

-45.19%

Metric	Value
150-day SMA	$33.70
1D price change	-0.86%
1M price change	15.52%
1M total return	15.52%
1W price change	10.88%
1W total return	10.88%
1Y price change	92.88%
1Y return CAGR	92.97%
1Y total return	92.88%
20-day SMA	$38.58
200-day SMA	$31.90
3M price change	30.28%
3M total return	30.28%
50-day SMA	$38.85
50-day SMA vs 200-day SMA	50over200
52-week high	$51.10
52-week high date	2026-08-12
52-week low	$17.55
52-week low date	2025-11-07
6M price change	73.89%
6M total return	73.89%
All-time high	$51.10
All-time high date	2026-08-12
All-time low	$4.17
All-time low date	2025-02-18
Average true range (ATR)	$2.38
Average volume	390.6K
Beta (1Y)	1.09
Beta (2Y)	2.08
Beta (5Y)	2.28
Change from 52-week high	-14.36%
Change from 52-week low	149.35%
Change from all-time high	-14.62%
Change from all-time low	946.28%
Change from open	-1.66%
Day's gap	0.82%
Dollar volume	$14.4M
High price	$44.95
Low price	$43.63
Monthly RSI	66.89
Open price	$44.50
Position in 52-week range	9.85%
Premarket change	0%
Premarket close	$44.14
Premarket price	$44.14
Previous close	$44.14
Price vs 150-day SMA	29.49%
Price vs 20-day SMA	13.09%
Price vs 200-day SMA	36.79%
Price vs 50-day SMA	12.3%
Relative volume	0.84
Return from IPO open	89.74%
Return from IPO price	147.72%
RSI	66.52
Sharpe ratio	1.24
Sortino ratio	2.44
Volume	329.8K
Weekly RSI	66.01
YTD price change	56.49%
YTD total return	56.49%

Metric

Value

150-day SMA

$33.70

1D price change

-0.86%

1M price change

15.52%

1M total return

15.52%

1W price change

10.88%

1W total return

10.88%

1Y price change

92.88%

1Y return CAGR

92.97%

1Y total return

92.88%

20-day SMA

$38.58

200-day SMA

$31.90

3M price change

30.28%

3M total return

30.28%

50-day SMA

$38.85

50-day SMA vs 200-day SMA

50over200

52-week high

$51.10

52-week high date

2026-08-12

52-week low

$17.55

52-week low date

2025-11-07

6M price change

73.89%

6M total return

73.89%

All-time high

$51.10

All-time high date

2026-08-12

All-time low

$4.17

All-time low date

2025-02-18

Average true range (ATR)

$2.38

Average volume

390.6K

Beta (1Y)

1.09

Beta (2Y)

2.08

Beta (5Y)

2.28

Change from 52-week high

-14.36%

Change from 52-week low

149.35%

Change from all-time high

-14.62%

Change from all-time low

946.28%

Change from open

-1.66%

Day's gap

0.82%

Dollar volume

$14.4M

High price

$44.95

Low price

$43.63

Monthly RSI

66.89

Open price

$44.50

Position in 52-week range

9.85%

Premarket change

Premarket close

$44.14

Premarket price

$44.14

Previous close

$44.14

Price vs 150-day SMA

29.49%

Price vs 20-day SMA

13.09%

Price vs 200-day SMA

36.79%

Price vs 50-day SMA

12.3%

Relative volume

0.84

Return from IPO open

89.74%

Return from IPO price

147.72%

RSI

66.52

Sharpe ratio

1.24

Sortino ratio

2.44

Volume

329.8K

Weekly RSI

66.01

YTD price change

56.49%

YTD total return

56.49%

Metric	Value
Float	26.4M
Float percentage	56.58%
Shares change (QoQ)	0.63%
Shares change (YoY)	45.19%
Shares held by insiders	2.86%
Shares held by institutions	58.62%
Shares outstanding	46.7M
Short % of float	13.34%
Short % of shares	7.55%
Short ratio	9.2 days

Metric

Value

Float

26.4M

Float percentage

56.58%

Shares change (QoQ)

0.63%

Shares change (YoY)

45.19%

Shares held by insiders

2.86%

Shares held by institutions

58.62%

Shares outstanding

46.7M

Short % of float

13.34%

Short % of shares

7.55%

Short ratio

9.2 days

Septerna, Inc. (SEPN)

Price

Financial snapshot

Fair-value bridge

Latest news · SEPN

Valuation

Profitability

Balance sheet

Trading

Next earnings

Sector percentile context

All SEPN indicators

Profile and market data

Valuation

Profitability

Growth

Financial statements

Financial strength

Liquidity

Dividends and buybacks

Performance and technicals

Ownership and float

Deeper analysis on SEPN

Frequently asked questions