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Spruce Biosciences, Inc. (SPRB)

NASDAQ: SPRB · USD

$42.8

-1.74 (-3.9%)· Recorded snapshot

Market cap	123M
Net income (ttm)	-51.4M
EPS (ttm)	-$36.0
Shares out	2.9M
Volume	73,491.295
Beta	3.54

Market data

Price

Recent price action with selectable time range.

Financial snapshot

Net income (ttm): -51.4M
EPS (ttm): -$36.0
Market cap: 123M

Ticker	Name	Market cap	P/E	P/S	ROIC	5Y rev CAGR	1Y total return	Rating
EXAS	Exact Sciences Corp	—	—	—	—	—	—	Hold

Metric	Value
Amount currency	USD
CIK code	0001683553
Company name	Spruce Biosciences, Inc.
Country	United States
Country code	US
CUSIP number	85209E208
Earnings date	2026-08-12
Earnings time	bmo
Employees	22
Employees change	13
Employees growth	144.44%
Enterprise value	$34.4M
Exchange	NASDAQ
Financial currency	USD
Financial report date	2026-06-30
First seen	2026-05-09
Fiscal year end	December
Founded	2014
In index	RUSSELL2000
Industry	Biotechnology
Is primary listing	Yes
Is SPAC	No
ISIN number	US85209E2081
Last earnings date	2026-08-12
Last refreshed	2026-11-04
Last stock split date	2025-08-07
Last stock split type	Reverse
Market cap	$123M
Market cap category	Micro-Cap
Options	No
Price	$42.81
Price currency	USD
Sector	Healthcare
Stock price date	2026-11-03
Symbol	SPRB
U.S. state	California
Website	https://sprucebio.com

Metric

Value

Amount currency

USD

CIK code

0001683553

Company name

Spruce Biosciences, Inc.

Country

United States

Country code

CUSIP number

85209E208

Earnings date

2026-08-12

Earnings time

bmo

Employees

Employees change

Employees growth

144.44%

Enterprise value

$34.4M

Exchange

NASDAQ

Financial currency

USD

Financial report date

2026-06-30

First seen

2026-05-09

Fiscal year end

December

Founded

2014

In index

RUSSELL2000

Industry

Biotechnology

Is primary listing

Yes

Is SPAC

ISIN number

US85209E2081

Last earnings date

2026-08-12

Last refreshed

2026-11-04

Last stock split date

2025-08-07

Last stock split type

Reverse

Market cap

$123M

Market cap category

Micro-Cap

Options

Price

$42.81

Price currency

USD

Sector

Healthcare

Stock price date

2026-11-03

Symbol

SPRB

U.S. state

California

Website

https://sprucebio.com

Metric	Value
Earnings yield	-84.21%
FCF / EV yield	-124.28%
FCF yield	-34.76%
P/B ratio	1.41x
Price / tangible book value	1.47x
Sector forward P/E	23.32x
Sector P/E	49.47x

Metric

Value

Earnings yield

-84.21%

FCF / EV yield

-124.28%

FCF yield

-34.76%

P/B ratio

1.41x

Price / tangible book value

1.47x

Sector forward P/E

23.32x

Sector P/E

49.47x

Metric	Value
Profit per employee	$-2.3M
ROA	-40.03%
ROA (5Y)	-32.76%
ROCE	-43.45%
ROE	-105.98%
ROE (5Y)	-71.97%
ROIC	-46.91%

Metric

Value

Profit per employee

$-2.3M

ROA

-40.03%

ROA (5Y)

-32.76%

ROCE

-43.45%

ROE

-105.98%

ROE (5Y)

-71.97%

ROIC

-46.91%

Metric	Value
EPS growth years	1
Net income growth years	1
Revenue growth years	0

Metric

Value

EPS growth years

Net income growth years

Revenue growth years

Metric	Value
Capital expenditures	$-145,000
Depreciation and amortization	$891,000
EBIT	$-39.9M
EBITDA	$-39M
EPS	$-36.05
FCF per share	$-14.88
Financing cash flow	$122.7M
Free cash flow	$-42.8M
Free cash flow minus SBC	$-46.4M
Gross profit	$-23M
Investing cash flow	$-145,000
Net borrowing	$12.9M
Net cash flow	$79.9M
Net income	$-51.4M
Operating cash flow minus SBC	$-46.3M
Operating income	$-39.9M
Stock-based compensation	$3.7M

Metric

Value

Capital expenditures

$-145,000

Depreciation and amortization

$891,000

EBIT

$-39.9M

EBITDA

$-39M

EPS

$-36.05

FCF per share

$-14.88

Financing cash flow

$122.7M

Free cash flow

$-42.8M

Free cash flow minus SBC

$-46.4M

Gross profit

$-23M

Investing cash flow

$-145,000

Net borrowing

$12.9M

Net cash flow

$79.9M

Net income

$-51.4M

Operating cash flow minus SBC

$-46.3M

Operating income

$-39.9M

Stock-based compensation

$3.7M

Metric	Value
Book value per share	$30.42
Debt / equity	0.09
Interest coverage	-22.23
Long-term assets	$1.7M
Long-term liabilities	$8.2M
Net cash (debt)	$88.6M
Net cash / market cap	72.03%
Net cash growth	508.51%
Net debt / equity	-1.06
Piotroski F-Score	2
Property, plant and equipment	$523,000
Shareholders' equity	$83.7M
Tangible book value	$83.7M
Tangible book value per share	$30.42
Total assets	$102.9M
Total cash	$96.3M
Total debt	$7.7M
Total liabilities	$19.1M
WACC	23.39%

Metric

Value

Book value per share

$30.42

Debt / equity

0.09

Interest coverage

-22.23

Long-term assets

$1.7M

Long-term liabilities

$8.2M

Net cash (debt)

$88.6M

Net cash / market cap

72.03%

Net cash growth

508.51%

Net debt / equity

-1.06

Piotroski F-Score

Property, plant and equipment

$523,000

Shareholders' equity

$83.7M

Tangible book value

$83.7M

Tangible book value per share

$30.42

Total assets

$102.9M

Total cash

$96.3M

Total debt

$7.7M

Total liabilities

$19.1M

WACC

23.39%

Metric	Value
Current assets	$101.2M
Current liabilities	$11M
Current ratio	9.23
Net working capital	$-3.3M
Quick ratio	8.78
Working capital	$90.2M

Metric

Value

Current assets

$101.2M

Current liabilities

$11M

Current ratio

9.23

Net working capital

$-3.3M

Quick ratio

8.78

Working capital

$90.2M

Metric	Value
Buyback yield / dilution	-149.79%
Dividend yield	0%
Shareholder yield	-149.79%

Metric

Value

Buyback yield / dilution

-149.79%

Dividend yield

Shareholder yield

-149.79%

Metric	Value
150-day SMA	$51.72
1D price change	-3.91%
1M price change	-6.34%
1M total return	-6.34%
1W price change	-6.22%
1W total return	-6.22%
1Y price change	-61.12%
1Y return CAGR	-61.14%
1Y total return	-61.12%
20-day SMA	$43.50
200-day SMA	$55.47
3M price change	-0.05%
3M total return	-0.05%
3Y price change	-49.04%
3Y return CAGR	-20.12%
3Y total return	-49.04%
50-day SMA	$49.55
50-day SMA vs 200-day SMA	50under200
52-week high	$129.00
52-week high date	2025-11-10
52-week low	$38.06
52-week low date	2026-10-14
5Y price change	-87.83%
5Y return CAGR	-34.38%
5Y total return	-87.83%
6M price change	-25.26%
6M total return	-25.26%
After-hours change	1.15%
After-hours close	$42.81
After-hours price	$43.30
All-time high	$2,670.01
All-time high date	2020-11-27
All-time low	$4.28
All-time low date	2025-04-29
Average true range (ATR)	$2.81
Average volume	78.4K
Beta (1Y)	-0.03
Beta (2Y)	-10.92
Beta (5Y)	3.54
Change from 52-week high	-66.81%
Change from 52-week low	12.48%
Change from all-time high	-98.4%
Change from all-time low	901.4%
Change from open	-4.87%
Day's gap	1.01%
Dollar volume	$3.1M
High price	$45.63
Low price	$42.51
Monthly RSI	42.92
Open price	$45.00
Position in 52-week range	9.62%
Premarket change	0%
Premarket close	$42.81
Premarket price	$42.81
Previous close	$44.55
Price vs 150-day SMA	-17.22%
Price vs 20-day SMA	-1.59%
Price vs 200-day SMA	-22.83%
Price vs 50-day SMA	-13.61%
Relative volume	0.94
RSI	43.05
Sharpe ratio	-0.73
Sharpe ratio (3Y)	0.54
Sharpe ratio (5Y)	0.4
Sortino ratio	-0.92
Sortino ratio (3Y)	5.16
Sortino ratio (5Y)	3.4
Volume	73.5K
Weekly RSI	42.17
YTD price change	-50.86%
YTD total return	-50.86%

Metric

Value

150-day SMA

$51.72

1D price change

-3.91%

1M price change

-6.34%

1M total return

-6.34%

1W price change

-6.22%

1W total return

-6.22%

1Y price change

-61.12%

1Y return CAGR

-61.14%

1Y total return

-61.12%

20-day SMA

$43.50

200-day SMA

$55.47

3M price change

-0.05%

3M total return

-0.05%

3Y price change

-49.04%

3Y return CAGR

-20.12%

3Y total return

-49.04%

50-day SMA

$49.55

50-day SMA vs 200-day SMA

50under200

52-week high

$129.00

52-week high date

2025-11-10

52-week low

$38.06

52-week low date

2026-10-14

5Y price change

-87.83%

5Y return CAGR

-34.38%

5Y total return

-87.83%

6M price change

-25.26%

6M total return

-25.26%

After-hours change

1.15%

After-hours close

$42.81

After-hours price

$43.30

All-time high

$2,670.01

All-time high date

2020-11-27

All-time low

$4.28

All-time low date

2025-04-29

Average true range (ATR)

$2.81

Average volume

78.4K

Beta (1Y)

-0.03

Beta (2Y)

-10.92

Beta (5Y)

3.54

Change from 52-week high

-66.81%

Change from 52-week low

12.48%

Change from all-time high

-98.4%

Change from all-time low

901.4%

Change from open

-4.87%

Day's gap

1.01%

Dollar volume

$3.1M

High price

$45.63

Low price

$42.51

Monthly RSI

42.92

Open price

$45.00

Position in 52-week range

9.62%

Premarket change

Premarket close

$42.81

Premarket price

$42.81

Previous close

$44.55

Price vs 150-day SMA

-17.22%

Price vs 20-day SMA

-1.59%

Price vs 200-day SMA

-22.83%

Price vs 50-day SMA

-13.61%

Relative volume

0.94

RSI

43.05

Sharpe ratio

-0.73

Sharpe ratio (3Y)

0.54

Sharpe ratio (5Y)

0.4

Sortino ratio

-0.92

Sortino ratio (3Y)

5.16

Sortino ratio (5Y)

3.4

Volume

73.5K

Weekly RSI

42.17

YTD price change

-50.86%

YTD total return

-50.86%

Metric	Value
Float	2M
Float percentage	70.18%
Shares change (QoQ)	77.18%
Shares change (YoY)	149.79%
Shares held by insiders	3.45%
Shares held by institutions	51.06%
Shares outstanding	2.9M
Short % of float	25.89%
Short % of shares	18.17%
Short ratio	5.9 days

Metric

Value

Float

Float percentage

70.18%

Shares change (QoQ)

77.18%

Shares change (YoY)

149.79%

Shares held by insiders

3.45%

Shares held by institutions

51.06%

Shares outstanding

2.9M

Short % of float

25.89%

Short % of shares

18.17%

Short ratio

5.9 days

Spruce Biosciences, Inc. (SPRB)

Price

Financial snapshot

Fair-value bridge

Latest news · SPRB

Valuation

Profitability

Balance sheet

Trading

Next earnings

Sector percentile context

All SPRB indicators

Profile and market data

Valuation

Profitability

Growth

Financial statements

Financial strength

Liquidity

Dividends and buybacks

Performance and technicals

Ownership and float

Deeper analysis on SPRB

Frequently asked questions